Evaluation of Some Clinical Chemistry Parameters of Wistar Rats Induced with Staphylococcus aureus from Clinically Diagnosed Pneumonia Patients
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2021, Vol 5, Issue 1
Abstract
The effect and extent of changes in some clinical chemistry parameters associated with pneumonia caused by Staphylococcus aureus were investigated in serum samples of Wistar rats. A total of 1500 samples were collected randomly. The serum samples were tested for sodium, potassium, urea, creatinine and chloride by colorimetric methods. The concentrations of sodium ranged from 133.6±4.615 to 143.8±6.906, potassium values ranged from 5.78±1.26 to 8.02±0.779, urea gave a range of 10.143±0.69 to 14.444±2.404, chloride values ranged from 94.8±2.683 to 104.142±8.49, while creatinine values ranged from 0.489±0.033 to 1.7±2.404. The results indicated that staphylococcus aureus has a significant effect on the electrolyte balance causing hyperkalemia and decreased levels of sodium and chloride when compared with the normal range. It had a remarkable effect on creatinine level with only slight effect on urea. There is need to monitor the electrolyte levels in cases of staphylococcus aureus infection since alteration in the electrolyte levels could be harmful to health.
Authors and Affiliations
Enwa FO*, Jemikalajah JD, Adjekuko C and Ogbare CB
Keywords
Related Articles
- EP ID EP748522
- DOI 10.23880/oajpr-16000225
- Views 82
- Downloads 0
In-Vivo Toxicity Assessment of Stem Bark Extracts of Spondias mombin (Linn) on Male and Female Albino Rats
Spondias mombin is depends on for various herbal remedies for the treatment of numerous health conditions. This study is to evaluate the In-vivo toxic effect of Stem bark extracts of Spondias mombin on in male and female...
A Review on Formulation and In-Vitro Evaluation of Sustained Release Tablet of Isoniazide by Using Natural and Synthetic Polymer
The goal of this study was to combine many polymers to create an isoniazide tablet with a sustained release. In this piece of work, guar gum, xanthum gum, and eudragit L100 are the polymers employed. The FTIR and UV ana...
Healthful Plants in COVID-19: Progression and Limitations
Presently, research is going for the evolution of treatment for avoidance of novel pandemic Covid-19. Despairness among communities (especially within the middle class or low economic people), due to lockdown and econom...
Facile Synthesis of Copper Sulphide Nanoparticles using Trichoderma Herzlianism and Antibacterial Efficiency Enhancement by Gentamicin Sulfate
The application of biosynthesized semiconductor nanomaterials has gained recent attention towards pathogenic bacteria. This study reports cost- effective, eco- friendly biosynthesis of copper sulphide nanoparticles (CuS...
Formulation and Evaluation of Co-Processed Excipient
The main purpose of the current review article is to provide a comprehensive overview of the latest developments in assistive technology and the mechanisms involved in the development of those assistants. Architectural...