Evaluation of Stress Ulcer Prophylaxis Benefits and Outcomes: A Simple Literature Review
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 10
Abstract
<strong>Background: </strong>One of the commonest complications in critically ill patients is stress related mucosal disease (SRMD). It can be associated with increase in the risk of development of overt gastrointestinal bleeding. As a result, a lot of literatures have been done to evaluate the pathogenesis that stands behind its development, and assessment of the measures that can be used to lower the risk of its 'occurrence. <strong>Aim of the Work: </strong>In this review we aimed at discussing the pathogenesis that stands behind stress ulcer development, Also, discussing the role of anta- acid as a prophylaxis against harms and benefits. In addition to providing an intensive study that analyzed the recent literatures considered this field of study. <strong>Methodology:</strong> A comprehensive search was done using biomedical databases; Medline, and Pubmed, for studies concerned with assessment of stress ulcer prophylaxis. Keywords used in our search through the databases were as; “stress ulcer”, “stress ulcer prophylaxis”, “stress ulcer in ICU patients”. <strong>Conclusion: </strong>Stress related mucosal disease is associated with increase in the risk of clinically overt gastrointestinal bleeding. As a result, patients who require mechanically ventilation for more than 48 h and those with a manifest of coagulopathy are highly recommended for having stress ulcer prophylaxis (SUP). Anta- acid such as Proton Pump Inhibitors (PPIs) and histamine 2 receptor antagonists (H2RA) help in prevention of gastrointestinal bleeding, but did not have any effect on mortality risk reduction. Still further prospective randomizes trials needs to be done to evaluate our scientific research survey to guide the physicians in making a decision about the use of SUP in ICU patients.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584349
- DOI 10.12816/ejhm.2018.11356
- Views 127
- Downloads 0
Consanguinity between Parents and Risk of Epilepsy among Children in Northern Saudi Arabia
<strong>Background:</strong> Epilepsy is one of the most common neurological disorders in childhood. There are various risk factors that could lead to epilepsy. However, a few studies have shown that there is a strong li...
Inflammatory Bowel Disease in Systemic Lupus Erythematosus Patients: A Meta-analysis
<strong>Background: </strong>Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with features of multisystem involvement, relapsing and remitting course. Gastrointestinal system affection is...
Respiratory Aspects of Approach to Neonatal Resuscitation
<strong>Introduction: </strong>Around 10% of live births globally require immediate intervention, and 4 million neonatal deaths happen in a year, where one fourth of them are due to asphyxia. Regular respiration may fail...
Study of Automated Red Blood Cells Parameters in Correlation with Routine RBCs Morphology by Smear Review
Background: sysmex XT 1800i coulter is a hematology analyzer incorporating new electronic and mechanical design with advanced algorithm technology to perform CBC. The principles of sysmex XT1800 are electrical impedance...
Prehospital Tracheal Intubation versus Emergency Department Intubation for Trauma Patients
<strong>Background:</strong> Patients with severe traumatic brain injury (TBI) are at high risk for airway obstruction and hypoxia at the accident scene, and routine prehospital endotracheal intubation has been widely ad...