Evaluation Of Synergistic Effects Of Gongronema Latifolium And Piper Guineense Ethanol Extracts On Selected Biochemical Indices In Ethanol Exposed Wistar Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Combination therapy has been identified as a promising strategy to improve disease management. This work was designed to estimate the synergistic effects of Gongronema latifolium and Piper guineense in selected biochemical indices in ethanol exposed wistar rats. A total of thirty five wistar rats were used for this study. It was grouped into A, B and C, with C subdivided into five; C1, C2, C3, C4 and C5. Groups B and C were exposed to 70 % ethanol for seven days, and further treated group C1-C3 with the combine extract100-300 mg/kg respectively while group C4 and C5 were treated with 400 mg/kg and 500 mg/kg of separate doses of the two plants extract for 21 days ,thereafter,the blood samples were collected and assay for biochemical indices, the results obtained were analysed using ANOVA. The results revealed that liver marker enzymes increased after exposure to ethanol whereas treatment with the extracts significantly (p <0.05) decreased AST, ALP, ALT, total bilirubin and total cholesterol in groups C1-C3. While the total protein increased significantly compared to control groups and individual separate doses. Selected biochemical parameters due to ethanol toxicity in rats fed chronically with high dose of ethanol were altered. This study indicates that treatment with combined extract could reverse damages due to ethanol toxicity than separate doses.
Authors and Affiliations
Ali Fredrick U, Ominyi 1 M. C. ,, Ogbanshi M. E, Nwankwo O. V. U. , 1, Ebenyi L. N. ,, Eze U. S. 3, Ezenwali M . O. 4
Keywords
Related Articles
- EP ID EP384915
- DOI 10.9790/3008-1103042934
- Views 96
- Downloads 0
Antimicrobial and Phytochemical Screening of Seaweeds: Enteromorpha intestinalis and Ulva lactuca Collected from Indian Sunderbans Delta Region
The aim of this study was to evaluate the antimicrobial activities of two green seaweeds: Enteromorpha intestinalis and Ulva lactuca collected from the Matla river of Indian Sunderbans Delta. Both seaweeds showed antibac...
Tranexamic Acid Use in the Total Hip and Total Knee Arthroplasty Population at an Academic Medical Center: a Retrospective Review of Postoperative Outcomes
Purpose: Excessive blood loss and subsequent blood transfusions in orthopedic procedures have been associated with considerable morbidity and mortality. The primary objective of this study was to determine the incidence...
Effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt fed Wistar rats
This study examined the effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt-fed wistar rats. Twenty male wistar rats (200-250g) were randomly assigned into four groups (n=5):...
Effect of Additive Tamoxifen Citrate to SMART Medium on Human Sperm Parameters during In vitro Sperm Activation
This study was aimed to investigate the effect of addition of tamoxifen citrate on the outcome of in vitro human sperm activation. One hundred semen samples for fertile and infertile men were randomly collected from the...
Pine Bark Extract Protects Against Oxidative Stress Induced By Recurrent Hypoglycemia In Rats.
The present work was designed to evaluate the role of pine bark extract (PBE) in protecting rats from oxidative stress produced by recurrent hypoglycemia. The animals were grouped as the following: control group, PBE-tre...