EVALUATION OF THE ANTI HYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF ROOT OF HELIOTROPIUM INDICUM IN STREPTOZOTOCIN AND ALLOXAN INDUCED DIEBETIC RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The root of Heliotropium indicum is reported to have good medicinal values in traditional system of medicines. Commonly called as Indian Turnsole, is a herb with slightly woody at base. The present study highlights the anti hyperglycemic activity of Methanolic extract of root of Heliotropium Indicum in Streptozotocin (60mg/kg i.p) for 15days and Alloxan (120mg/kg i.p) for 21 days induced Diabetic rats. The anti hyperglycemic activity of oral administration of Methanolic extract of root of Heliotropium Indicum at 100mg/kg, 250mg/kg, and 500mg/kg was investigated in diabetic rats. Glibenclamide10mg/kg, p.o was used as standard drug. The extract decreased the blood glucose level, feed and water intake as well as triacylglycerols at the three doses investigated while the best result was obtained at 500 mg/Kg for both STZ and Alloxan induced diabetic rats. In addition, the weight loss of diabetic-treated rats was markedly normalized at all doses. The glucose tolerance level of diabetic animals was effectively reduced to near normal level after 90 min of extract administration especially at the dose of 250 and 500 mg/Kg. Further, the Histopathological examination of pancreas supported the anti-Hyperglycemic activity of test extract. All the data was analyzed by using one way analysis of variance (ANOVA) followed by multiple comparison Dunnett’s test and the acceptance criteria was P<0.05.
Authors and Affiliations
Aqheel MA Janardhan M, Durrai vel S
Keywords
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