EVALUATION OF THE ANTIBACTERIAL, CYTOTOXIC AND INSECTICIDAL ACTIVITIES OF HIBISCUS SABDARIFFA BARKS
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
The present study was designed to investigate the antibacterial, cytotoxic and insecticidal activities of the methanol (85%) extract of barks of Hibiscus sabdariffa (MEHS). Antibacterial tests were done against six Gram-positive and eight Gram-negative bacteria using disc diffusion method. The extract showed the highest activity against Escherichia coli (14± 0.21 mm) followed by Shigella dysenteriae (13± 0.09), Sarcina lutea (13± 0.13mm), Shigella boydii (12± 0.12mm) and Staphylococcus aureus (12± 0.12mm) whereas inactive against Bacillus subtilis, B. megaterium, B. anthracis and B. cereus. The cytotoxic activities of crude extract was determined using Brine Shrimp lethality Bioassay and LC50 values of standard Vincristine sulphate as a positive control and the crude extract were found to be 0.21±0.19μg/ml and 9.605±0.21μg/ml respectively. In insecticidal study, MEHS showed the significant activity with 100% mortality rate of Tribolium castaneum at a dose of 50mg/ml with 12 hours and also showed the activity in a dose dependent manner. Key words: Hibiscus sabdariffa, Disc diffusion, Brine Shrimp lethality, Insecticidal activity
Authors and Affiliations
1Mst. Hajera Khatun , 2Mst. Luthfun Nesa , 3Al Imran Hosen , 1Shamiul Bashar , 1Sanchita Sarker , 1Md. Rashedul Islam
Keywords
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