EVALUATION OF THE EFFECT OF MAGNESIUM SULPHATE VS. CLONIDINE AS AN ADJUVANT TO EPIDURAL LEVOBUPIVACAINE IN PATIENTS UNDERGOING LOWER ABDOMINAL SURGERIES- A PROSPECTIVE,RANDOMISED AND DOUBLE-BLINDED STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 85
Abstract
BACKGROUND Various adjuvants can be added to local anaesthetics and administered in central neuraxial blockade to improve the speed of onset, quality and duration of analgesia with desirable sedation. Magnesium Sulphate and Clonidine are relatively harmless molecules, cost-effective and biological basis for their anti-nociception is promising. Therefore, in this study, Magnesium Sulphate was compared with Clonidine (α2- agonist) as adjuvant to Levobupivacaine in epidural anaesthesia. The aim of the study is to compare the effects of Magnesium Sulphate (50 mg) Vs. Clonidine (150 mcg) as an adjuvant to Epidural 0.5% Levobupivacaine in adult patients undergoing lower abdominal surgeries in a prospective, randomised and doubleblinded study. MATERIALS AND METHODS Hundred patients undergoing elective lower abdominal surgeries, aged between 18-50 years of either gender, belonging to ASA grade I and II were randomly divided into two groups and were subjected to epidural catheterisation with 16/18 G size and given epidural anaesthesia. Group LM- Consists of patients in whom 19 mL of 0.5% Levobupivacaine with Inj. Magnesium Sulphate – 50 mg (in 1 mL) was administered. Group LC- This group comprises of patients in whom 19 mL of 0.5% Levobupivacaine with Inj. Clonidine 150 µg (in 1 mL) was administered. RESULTS The mean time of onset of sensory and motor blockade in Magnesium Sulphate group is significantly less than that of Clonidine group. The duration of sensory blockade and post-operative analgesia was significantly prolonged in Clonidine group than that of Magnesium Sulphate group. Both the groups were similar in haemodynamic stability and side effects. CONCLUSION Addition of Magnesium Sulphate to epidural Levobupivacaine produced rapid onset and longer duration of post-operative analgesia with stable haemodynamics, minimal side effects and without any sedation. Addition of Clonidine to epidural Levobupivacaine produced significantly longer duration of analgesia when compared to Magnesium Sulphate but with sedation and fewer side effects.
Authors and Affiliations
Prasad Rao M, Ranganath T, Ch. Srinivas Rao, Sandeep Gurugubelli
Keywords
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- EP ID EP277622
- DOI 10.14260/jemds/2017/1286
- Views 81
- Downloads 0
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