EVALUATION OF THE EXTRACTS OF LEUCAS ASPERA ON BIOCHEMICAL PROFILES IN EXPERIMENTAL MODEL OF DIABETES MELLITUS (TYPE- I) IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The study was conducted to evaluate the effect of Leucas aspera leaves on experimental diabetes mellitus (type I) in rats in terms of alterations in biochemical profiles. Thirty rats were randomly divided into six groups of 5 rats in each. Group-I were fed on basal diet without any treatment, group-II induced diabetic models (type-I) (Alloxan monohydrate dissolved in sterile normal saline (150 mg/kgBW, ip)), group-III, IV, V and VI were induced diabetics and treated with extract of Leucas aspera (30,100,150 and 300mg/kg BW respectively, PO) twice daily in the morning and evening post prandially for thirty days respectively. The blood samples were collected on day 0, 10, 20 and 30 and were used for the analysis of biochemical profiles. The blood glucose (mg%) were consistently increased significantly (P<0.01) in groups II,III, IV V and VI till day 20 while in groups V and VI there was a significant (P<0.01) decline in the values on day 30. There was found to have profound effect in lowering the blood glucose levels in dose dependent manner. The study revealed that experimental diabetes mellitus (type-I) induced patho-biochemical changes were ameliorated more effectively by ethanolic extract of Leucas aspera in dose dependent manner.
Authors and Affiliations
T. Tukaram , Parvati C. V. , Venkat Rao, Prakash Patil , Sreenivas Rao
Keywords
Related Articles
- EP ID EP124728
- DOI -
- Views 100
- Downloads 0
PHYTOCHEMICAL INVESTIGATION AND ANTHELMINTIC ACTIVITY OF CELOSIA CRISTATA LEAF EXTRACTS
Development of anthelmintics from medicinal plants might be served as an alternative source for the conventional anthelmintic drugs. The present study was attempted to assess the possible anthelmintic activity for chloro...
EFFECT OF ANISOCHILUS DYSOPHYLLOIDES BENTH. (LAMIACEAE) ON CARBONTETRA CHLORIDE (CCl4) INDUCED HEPATOTOXICITY IN RATS
The hepatoprotective effect of Anisochilus dysophylloides was evaluated on carbon tetrachloride (CCl4) induced in rats. The liver marker enzymes such as serum glutamate oxaloacetate (SGOT), serum glutamate pyruvate trans...
ISOCRATIC SEPARATION OF FOUR BETA BLOCKERS WITH AMLODIPINE BY C18 RP-HPLC: APPLICATION TO AMLODIPINE DETERMINATION IN PHARMACEUTICAL DOSAGE FORMS
This method described for the successful separation of a beta blockers with amlodipine by RP-HPLC on a C18 column with UV detection. One of the key goals of High Performance Liquid Chromatography technique is to achieve...
PRELIMINARY PHYTOCHEMICAL INVESTIGATION AND ANTHELMINTIC ACTIVITY OF ACACIA SUMA (ROXB) BARKS
The present work was conducted to investigate the preliminary phytochemical studies and anthelmintic activities on the bark of Acacia suma (Roxb.) Family- Fabaceae against adult Indian earthworms, Pheretima posthuma. Var...
DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF OCULAR INSERT CONTAINING ERYTHROMYCIN
Ocular drug delivery is one of the most fascinating and challenging tasks being faced by the Pharmaceutical researchers. The challenges to the formulator are to circumvent the protective barriers of the eye without causi...