EVALUATION OF THE HYPOGLYCEMIC AND ANTI-HYPERGLYCEMIC ACTIVITIES OF AQUEOUS AND HYDROETHANOLIC EXTRACTS OF ERYTHROCOCCA ANOMALA LEAVES IN RAT.
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 4
Abstract
Erythrococca anomala (Euphorbiaceae) is an annual medicinal plant, widely used in traditional medicine in Cote d’Ivoire and sub-Saharan Africa as an anti-inflammatory, laxative and purgative. In the present work, the aim was to evaluate the hypoglycemic and anti-hyperglycemic activity of the aqueous and hydroethanolic extracts of the leaves of this plant in the rat. The blood glucose was determined using a glucose reader Test strips). Administered orally at doses of 100 and 200 mg / kg body weight the extracts induce dose-dependent hypoglycemia in the rat. These aqueous and hydroethanolic extracts at a dose of 200 mg / kg body weight significantly reduced the hyperglycemia caused by administration by glibenclamide, the reference anti-hyperglycemic molecule (10 mg / kg body weight). Oral glucose at a dose of 5 mg / kg body weight to the rat.
Authors and Affiliations
Miezan Bile Aka Patrice
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