Evaluation of the Relationship between Mucosal Diseases and Faecal Calprotectin Levels in Children who Underwent Upper Gastrointestinal System Endoscopy
Journal Title: The Journal of Pediatric Research - Year 2020, Vol 7, Issue 3
Abstract
Aim: In this study, the correlation of faecal calprotectin (FC) levels with endoscopic and histopathological findings was evaluated in children who underwent upper gastrointestinal system (UGIS) endoscopy. Materials and Methods: The patients aged 4-18 years admitted to our endoscopy unit were included in this study. Faecal samples were collected on the day participants presented for the study. A calprotectin assay was performed on the faecal samples using enzyme-linked immunosorbent assay kits. FC levels were compared with those of children with normal histopathology. Results: The FC levels of 112 children included in this study were evaluated according to their histopathological diagnoses. Their FC levels were not found to be significantly higher than those in healthy children. No significant difference was found in the FC levels of participants with or without signs of inflammation in the esophagus, stomach and duodenum. In those participants with chronic gastritis, Helicobacter pylori (H. pylori) gastritis, reflux esophagitis or celiac disease, FC levels above cut-off values were observed. However, no significant difference was found in those participants with normal endoscopic findings. There was no significant difference in FC levels between similar regions of the UGIS with or without signs of inflammation. A positive correlation was discovered between eosinophil counts and FC levels in patients with H. pylori gastritis and esophagitis. Conclusion: The diagnostic value of FC levels in UGIS diseases was not sufficient to establish a definitive diagnosis in our study.
Authors and Affiliations
Maşallah Baran, Yeliz Çağan Appak, Fatma Demet Arslan, Dudu Solakoğlu Kahraman, Miray Karakoyun, İnanç Karakoyun, Büşra Emir, Gülden Diniz
Keywords
Related Articles
- EP ID EP685494
- DOI 10.4274/jpr.galenos.2019.65049
- Views 163
- Downloads 0
The Impact of e-Health Literacy on Health Promotion Behaviors of High School Students
Aim: The aim of this study was to investigate the effects of e-health literacy on health promotion behaviors on high school students. Materials and Methods: This descriptive, cross-sectional and relational study was con...
Does Celiac Disease Effect Electrocardiographic Markers of Arrhythmic Events in Children?
Aim: Cardiac abnormalities associated with celiac disease (CD) have been reported. However, changes in electrocardiographic (ECG) parameters in children with CD have not been previously evaluated in the literature. In th...
Infantile Colic in Infants Aged One-Six Months and the Practices of Mothers for Colic
Aim: The aims of this study were to explore the infantile colic in infants from 1-6 months of age, and the mother’s practices to eliminate colic and the relationships between infantile colic scores and sample characteris...
Thyroid Function in Obese Children and Adolescents and its Relationships with Metabolic Parameters
Aim: The purpose of this study was to evaluate levels of free thyroxin (T4) and thyroid-stimulating hormone (TSH) in obese children and adolescents, and to identify potential correlations between glucose and lipid metabo...
The Relationship of Chronic Spontaneous Urticaria with Anxiety and Depression in Children
Aim: Chronic spontaneous urticaria (CSU) is characterized by urticaria recurring almost every day and lasting more than six weeks, with either known or unknown etiology. It may lead to various psychiatric disorders. Our...