Evaluation of the teratogenic potential of chloramphenicol to induce the appearance of cleft palate in Wistar rats
Journal Title: RSBO - Year 2010, Vol 7, Issue 2
Abstract
Introduction: Chloramphenicol is an antibiotic with controversial use during pregnancy for easily crossing the placental barrier and achieving high concentrations in the fetus. Objective: The aim of this study was to evaluate the teratogenic potential of chloramphenicol to induce cleft palate in rats. Material and methods: 10 female Wistar rats were used to perform the mating, allocated into two groups: G1– 5 female rats received 0.5 mg/kg of sodium chloride intramuscularly from the 14th to the 17th day of pregnancy (control); G2 – 5 female rats received 0.5 mg/kg of chloramphenicol intramuscularly from the 14th to the 17th day of pregnancy. Cesareans were performed in the 20th day of pregnancy. The fetuses’ heads were removed and clinically examined with the aid of a stereoscopic magnifying glass for the diagnosis of cleft palate.Results: The fetuses of G1 or G2 did not present cleft palate.Conclusion: Chloramphenicol does not have the teratogenic potential to induce cleft palate in rats.
Authors and Affiliations
Heloísa STEFFENS, Andréa BRANDÃO, Odilon GUARIZA FILHO, Ana GRÉGIO, João STEFFENS
Keywords
Related Articles
- EP ID EP113312
- DOI -
- Views 183
- Downloads 0
Subepithelial connective tissue graft: a case report
Introduction and objective: Marginal tissue recession represents a common condition in Periodontology. Miller’s Classes I and II recessions, in which the etiological factors are well diagnosed and eliminated, show great...
Clinical conduct of the dentist toward the dental avulsion: Literature review
The dental avulsion is characterized for the dislocation of the tooth from its socket. The knowledge about the clinical conduct after trauma is not unanimous. The present study has compiled several works about dental avu...
Clinical, microbiological and radiographic considerations observed around dental implants
Introduction: Periimplantitis is characterized by the inflammation of the soft tissues, bleeding, and suppuration, as well as rapid bone loss around dental implants that are in function. The lesion is associated wi...
Assessment of maxillary and mandibular incisors inclination in individuals with class II division 1 malocclusion, according to the facial pattern
Introduction and objective: The aim of this study was to cephalometrically evaluate the maxillary and mandibular incisors inclination in individuals with Angle class II division 1 malocclusion,and then correlate these in...
Avaliação da eficácia dos diferentes instrumentos rotatórios no retratamento endodôntico
Objective: The purpose of this study was to compare in vitro the effectiveness of removing guta-percha from root canals using differents rotatory instruments. Material and methods: Sixty human inferior premolars have bee...