Evaluation of Wound Healing Effect of Eel Mucus Ointment (Belutidine) in Mice by Incision Model
Journal Title: Journal of Natural Remedies - Year 2018, Vol 18, Issue 1
Abstract
Background: It has been reported by the Ministry of Health that the prevalence of wounded and worsening events is increasing in Indonesia. This situation requires more intensive attention. Eel mucus has been an alternative treatment of wounds in some parts of Indonesian society since ancient times. Aim and Objectives: To explore the effectiveness of eel mucus ointment as a natural wound healing product. Material and Methods: This experimental study used 45 mice divided into 3 groups; 15 mice in each group. All mice were aseptically wounded 1.5 cm on their anterior region of back skin using a sterile scalpel, and then treated with placebo, povidone iodine ointment, and with eel mucous ointment (Belutidine). On the third, sixth and ninth day, the mice were sacrificed. Data on wound length were taken on 9th day. Microscopic data of histologic slides collected were: number of neutrophil, mono-nuclear, neo-vascular and fibrosis cells. Data were analyzed using statistical analysis. Results: There was a significant difference in wound length between the groups (p = 0.008). The number of mono-nuclear cells on the third day was different significantly among the groups (p = 0.008). There was no significant difference of the overall observed cells on day 6 and there was a difference in mean number of neutrophils and fibrosis on day nine (p < 0.05). On day nine, the group treated with eel mucus ointment had the highest number of mean of neo-vascular and fibrosis cells. Conclusion: Eel mucous ointment is effective for wound healing.
Authors and Affiliations
Muhammad Thorieq Ali, Muhammad Fadli Ashari
Keywords
Related Articles
- EP ID EP334732
- DOI 10.18311/jnr2F20182F18107
- Views 103
- Downloads 0
Historical Perspectives of Nutrition Science: Insights from Ayurveda
<p>Nutrition is the science that interprets the interaction of food in relation to maintenance, growth, health and disease of an organism. The history of nutrition science and dietetics can be traced back as far as histo...
Comparing the Effect of Coconut Oil Pulling Practice with Chlorhexidine Mouth Wash in Plaque Induced Gingivitis by Evaluation of Salivary Biochemical Marker – A Comparative Interventional Study
Background: Oil pulling is an oral hygiene practce and is described in the ancient Ayurvedic literature. Materials and Methods: A total of 30 subjects with plaque related mild – moderate gingivits in the age Group of 18-...
Amelioration of Trichosanthes lobata in Paracetamol-Induced Hepatic Damage in Rats: A Biochemical and Histopathological Evaluation
The aim of the present work is to investigate the possible therapeutic potential of Trichosanthes lobata in paracetamol induced hepatic damage in rats. The hepatotoxicity was induced in rats by administration of paraceta...
Chemical Composition, Larvicidal and Antibacterial Activity of the Essential Oil of <i>Trachyspermum ammi</i> Fruit
<em>Trachyspermum ammi</em> fruits (<em>T. ammi</em>) are widely sold and used in the Arabian herbal markets, which requires scientific investigations about its biological activities. The GC-MS analysis of the essential...
Anticancer and DNA-Protecting Potentials of <i>Spilanthes acmella</i> (Toothache Plant) Grown in Mizoram, India
The toothache plant, <em>Spilanthes acmella</em> (L.) Murray, is an important culinary and medicinal plant. Here, we study its probable properties as a protective agent for DNA damage and cell proliferation, the two mole...