Evidence Based Alzheimer’s Like Pathology in Normal Aging Brain
Journal Title: Scholars International Journal of Anatomy and Physiology - Year 2018, Vol 1, Issue 2
Abstract
Abstract:The evidence-based morphometric study was carried out to ascertain the Alzheimer’s like pathology in normal aging brain in Navi Mumbai, India.35 normal human cadaver brain specimens were acquired from MGM Medical College, Navi Mumbai, and (Alzheimer`s disease brains) NIMHANS, Bangalore, after meeting the ethical clearance from MGMIHS. Control group of Alzheimer’s disease was considered. A history based on CERAD criteria was used for informent scale. We divided the total brains into five groups; group I (20 to 39 years), group II (40 to 59 years), group III (60 to 79 years), group IV (>80 years) and a control-group V (Alzheimer`s brain specimen). We recorded gross features, cortical thickness and the ventricular dilatation in each brain. The chi - square test was applied for calculating cortical atrophy and ventricular dilatation of various age groups. One way ANOVA test was applied to the relation between different age groups using the SPSS19 software. In our study, the mean reduction in brain weight was evident from the 6th decade of life with minimum weight of 800gm (951.90±101.3gm). A substantial difference in the average weight of the brain in different age group was observed (p<. 001). Cortical atrophy and ventricular dilatation was evident of 20% in group II, 60% in group III and 100% in group IV (p<. 01). Keyword:Alzhimers disease, Aging, Atrophy, Degeneration, Dementia.
Authors and Affiliations
Pravin Raghunath Rathod, Monali D Sonawane, Aruna Mukherjee
Keywords
Related Articles
- EP ID EP401309
- DOI -
- Views 104
- Downloads 0
Anatomy of Suprascapular Notch and its Association with Suprascapular Nerve Entrapment Syndrome
Abstract:This study deals with the morphological variations of suprascapular notch of dry scapula. A total of 200 human dry scapulae which were obtained from the Department of Anatomy of various medical colleges were ana...
A Study on Anthropometric Dimension of the Foot amongst Undergraduate Students in Malaysia
The foot anthropometric data provides highly important information for anatomist, forensic scientist, physical anthropologist, health science, sports science &medical science professionals and also footwear industrial pe...
Attachment of the Chordae to the Tricuspid Valve – A Study
Abstract:The structures supporting the tricuspid valve leaflets are called chordae tendinae. They are collagenous. They are also known as tendinous cords. The tricuspid valve cusps are attached into the atria, during ven...
Height: Ulna Ratio-A Method of Stature Estimation Used in Comparing the Stature of Ikwerre and Kalabari Tribes in Rivers State, Nigeria
Abstract:This study was aimed at comparing the height predicted from ulna lengths in the adults (aged between 20 to 50 years old) from the two different ethnic groups. Analysis of stature of 600 healthy males and 600 fem...
A Prospective Study of Diagnostic Hysteroscopy in Abnormal Uterine Bleeding and its Correlation with Histopathology in Rural Tertiary Care Hospital of Central India
Abstract:Abnormal uterine bleeding is the most common complaint in gynecology. Dilatation and Curettage is a blind procedure.Hysteroscopy has ushered in a new era in the evaluation of abnormal uterine bleeding. By direct...