EVIDENCE BASED UPDATE ON NSAIDS: OVERVIEW
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 4
Abstract
NSAIDs have a more significant effect on pain resulting from the increased peripheral sensitization that occurs during inflammation and leads nociceptors to respond to stimuli that are normally painless. The goal of this paper is to review current literature on history, mechanisms of action, efficacy, and tolerability of OTC analgesics (NSAIDS). Relatively new and potential future indications for these drugs are also discussed. Literature search was performed in January 2012 in the following electronic database: Medline, Ebsco, Pubmed, Dove Press, Bentham Publishers, and the Cochrane Library. We collected literature from 1968 to January 2012, search terms were as follows; complication, use, prevention and mechanisms of NSAIDs. This review has enlighten the pharmacological basis for the common therapeutic approaches to pain management and also elucidate the diagnosis of acute and chronic exposure of NSAIDs poisoned patients. The article briefly describe about the classification, clinical features, diagnosis, pathogenesis, fatal dose, autopsy features and management of the NSAIDs poisoning. Finally, we touch on prevention and newer therapy that might be effective in the near future.
Authors and Affiliations
Vijaya kumar S1 , Sasi kala M
SPECTROPHOTOMETRIC ESTIMATION OF ZIDOVUDINE IN BULK AND TABLET DOSAGE FORM
A simple, rapid and economical spectrophotometric was developed for the estimation of zidovudine in bulk and tablet dosage forms. The results obtained were found to be good and sensitive. The method was validated and was...
A SHORT COMMUNICATION ON FORMULATION AND EVALUATION OF DEPILATORIES
Depilatory is a cosmetic preparation used to remove hair from the skin on the human body. Currently, common active ingredients are calcium thioglycolate or potassium thioglycolate, which breaks down the disulfide bonds i...
DENDRIMER: A COMPLETE DRUG CARRIER
Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules.As a result of their unique behaviour; dendrimer is suitable for a wide range of biomedical and industrial applicat...
LIQUISOLID SYSTEMS - AN EMERGING STRATEGY FOR SOLUBILIZATION & DISSOLUTION RATE ENHANCEMENT OF BCS CLASS-II DRUGS
Now-a day‟s efforts are ongoing to enhance the oral bioavailability of lipophilic drugs/water insoluble drugs in order to increase their clinical efficacy. One of the most popular approaches includes Liquisolid technique...
A MINE OF MEDICINAL USES: OCIMUM SANCTUM, THE HOLY BASIL
The medicinal plants are rich in secondary metabolites, which are potential sources of drugs and essential oils of therapeutic importance. One such plant of interest is Ocimum sanctum (Lamiaceae). Traditionally used sinc...