Examination of Mutations in the HBsAg and Polymerase Genes Induced by Pegylated Interferon Alpha and Oral Antivirals Used in the Treatment of Chronic Hepatitis B
Journal Title: Viral Hepatitis Journal - Year 2020, Vol 26, Issue 3
Abstract
Objectives: The Hepatitis B Virus is a virus having high mutation frequency due to having a high replication capacity and not having error correction capability in reverse transcription.It is aimed to examine the mutations created by the oral antivirals used in CHB treatment on pol gene and S gene, to determine the clinical and epidemiological significance of these mutations, and to specify the development of drug resistance in long terms and the results it may cause. Secondly, it is aimed to determine whether the quantitative HBsAg titers are early markers for detecting drug resistance or not. Materials and Methods: Correlation analyses were performed with monitoring qHBsAg levels and HBsAg (S/Co) and HBV-DNA levels of the patients. Results: It was seen in the correlation analysis, a statistically significant middle level correlation existed between the initial qHBsAg and HBV-DNA levels. It was concluded that the efficiency of qHBsAg levels on making diagnosis is at a good degree to distinguish inactive HBsAg carriers and HBeAg negative CHB patients, and the cutoff value was determined as 2188 IU/mL.Conclusions: In order to understand the usability of HBsAg titres as a marker in early diagnosis of these mutations more comprehensive studies are required.
Authors and Affiliations
Elif Sargın Altunok, Sila Akhan, Murat Sayan
Keywords
Related Articles
- EP ID EP691652
- DOI 10.4274/vhd.galenos.2020.2020.0017
- Views 99
- Downloads 0
Genotype Distributions and Hepatitis B Coinfection in Hepatitis C Patients at a University Hospital
Objectives: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Comorbidity with the hepatitis B virus (HBV) leads to progressive fibrosis and severe liver disease. Our study aimed to determine H...
Diagnostic Performance of Non-invasive Fibrosis Indexes in Hepatitis B Related Fibrosis
Objectives: The aim of this study was to evaluate the diagnostic performance of non-invasive fibrosis markers [AST to platelet ratio (APRI), Fibrosis Index based on four factors (FIB-4) İndex, AST/platelet/GGT/Alpha-feto...
Investigating Hepatitis C, D and HIV Prevalance in Cases with Positive Hepatitis B Virus Antigen in a Tertiary Hospital and Examining Anti-HDV Positive Cases
Objectives: Hepatitis B infection has a faster and more progressive course in the presence of hepatitis C virus (HCV), HDV and human immunodeficiency virus (HIV) infections. The aim of this study was to determine anti-HC...
Is There an Association Between Hepatitis B and Atherosclerosis?
Objectives: Although hepatitis B infection can cause chronic disease, its association with atherosclerosis is a matter of debate. Retinopathy is an early marker for microvascular abnormalities of retinal circulation and...
Genotype Distribution of Hepatitis C Virus in Hatay Province of Turkey
Objectives: The treatment duration and response of chronic hepatitis C (CHC) are closely related to the genotypes of hepatitis C virus (HCV). This study aimed to determine the genotype distributions among CHC patients in...