EXPLORING THE COMPETENCE OF PHYTOCHEMICAL COMPOUNDS TO COMBAT ANTHRACNOSE DISEASE OF CUCUMBER -AN IN SILICO APPROACH
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: Anthracnose is one of the diseases of cucumber caused by the fungus Colletotrichum lagenarium. The enzymes of fungal melanin biosynthesis pathway act as a potential target for the synthetic fungicides. The present study aims to identify the rational phytochemical compound that exhibits inhibitory activity towards a key enzyme scytalone dehydratase (SCD) of melanin biosynthesis pathway.Methods: Phytochemical compounds with antifungal activity were screened from the conventionally used medicinal plants and docked with the target enzyme SCD.Results: The interaction amongst phytocompounds and the target SCD were evaluated. Five out of 20 compounds exhibited higher binding affinity compared to that of synthetic fungicide carpropamid.Conclusion: The current study revealed that the compounds exhibiting significant interaction with SCD might act as an efficient fungicide for the control of anthracnose disease of cucumber.
Authors and Affiliations
K. Priyadharsini, S. Saravanakumar, N Bharathi, J Ramlingam
Keywords
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