Exploring the Role of Remote Ischemic Preconditioning in Long Term Cognitive Impairment after Global IschemiaReperfusion-Induced Vascular Dementia in Mice
Journal Title: Journal of Clinical and Medical Research - Year 2020, Vol 2, Issue 5
Abstract
Aim: The aim of the present study is to explore the neuroprotective effects of remote ischemic preconditioning in long term cognitive impairment after global cerebral ischemia induced-vascular dementia in mice. Material and methods: The mice were subjected to global cerebral ischemia by occluding the bilateral common carotid arteries for 12 minutes followed by the 24 hours of the reperfusion. The remote ischemic preconditioning stimulus was delivered in the form of 4 cycles of ischemia/reperfusion for 5 minutes each. The cerebral ischemic injury induced-long term cognitive impairment-related learning and memory alterations was assessed using morris water maze, the motor performances of the animals were evaluated using rota-rod test and neurological severity score. The cerebral infract size of the brain were quantified using triphenyltetrazolium chloride staining. Results: Global cerebral ischemia causes long term memory impairment, decreases motor performances and increases the brain infract size in animals. The delivery of remote ischemic preconditioning stimulus significantly abolished the long-term cognitive impairment and ameliorates the motor performances as well as cerebral infract size in brain. Conclusion: The remote ischemic preconditioning mediates neuro protection against global cerebral ischemic injury induced long-term cognitive impairment.
Authors and Affiliations
Diwakar Sharma, Nirmal Singh, Amteshwar Singh Jaggi*
Keywords
Related Articles
- EP ID EP708409
- DOI https://doi.org/10.37191/Mapsci-2582-4333-2(5)-045
- Views 64
- Downloads 0
Editor Note Volume 3 Issue 1
The articles published in Volume 3, Issue 1 maintain the high standards for peer-reviewed journals. These articles are related to Pulmonary Tuberculosis, Animal Models, COVID-19 vaccines, Dentistry Data Analytics, and th...
Rares Diseases and Handicap: State of the Medical, Social and Health Policy in Developing Countries. Cameroon Case: About One Case: Cushing Disease
Rare's diseases and orphan's diseases, disability (orhandicap) are a reality throughout the world and a real public health problem in developing countries. The great precariousness in which the populations live increases...
Pulmonary Tuberculosis Mimicking Lung Cancer and Metastasis Radiologically- A Case Report
Tuberculosis (TB) is known to mimic several clinical conditions, especially malignancy. Pulmonary TB can present with pulmonary infiltration with or without mediastinal lymphadenopathy. TB often gets misdiagnosed in the...
Subungual Exostosis: Unusual Localization
Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor, it is more common on toes and develops mostly during adolescence and is considered rare in young children and on fingers [1]. Etiopathogenesi...
Effect of Fluoride Mouthwash in Iranian Schools: Treatment or Exacerbation of the Disease
Dental and oral health is an important part that plays a significant role in the quality of life of people in our society, especially children, but due to insufficient attention, tooth decay in the world is increasing ev...