Expression of Estrogen Receptor β in Hypothalamic Stem Cells
Journal Title: Journal of Evolving Stem Cell Research - Year 2017, Vol 1, Issue 2
Abstract
Neural stem cell activity at least partially accounts for the postweaning development of the sexually dimorphic nucleus of the preoptic area (SDN-POA) and estrogen selectively mobilizes neural stem cells in the 3rd ventricle stem cell niche (3VSCN). Here, we examined the expression of estrogen receptor β (ERβ) in the SDN-POA and the 3VSCN. A subset of cells within the SDN-POA--delineated with or without calbindin D28K (CB28)-immunoreactivity (ir)--exhibited ERβ-ir. The ependymal cells that expressed nestin within the 3VSCN also expressed ERβ. Interestingly, a few proliferating (Ki67 positive) cells within the 3VSCN and the hypothalamic parenchyma, including the SDN-POA, displayed ERβ-ir. In parallel, a subset of cells in the subventricular zone was double-labeled with nestin and ERβ or Ki67 and ERβ while the subgranular zone exhibited few such double-labeled cells. ERβ is expressed in hypothalamic stem cells that may regulate cell regenerative cycles.
Authors and Affiliations
Zhen He, Li Cui, Sherry A. Ferguson, Merle G. Paule
Keywords
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- EP ID EP262540
- DOI 10.14302/issn.2574-4372.jesr-17-1611
- Views 151
- Downloads 0
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