Expression of stem cell growth factor receptor CD117 (C-Kit) in breast neoplasms
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 2
Abstract
Aim study designed to correlate the histopathological grading and IHC of Breast cancers and also to study the expression of stem cell growth factor receptor CD117cKit in stromal component myoepithelial cells and ductal epithelial cells of nonneoplastic amp neoplastic breast lesionsMaterials and Methods A study of 50 women with breast neoplasm enrolled and their samples were examined by lumpectomy and mastectomy and fixed for immunohistochemistry with monoclonal rabbit antihuman cKit marker 46 microns sections were stained with Haematoxylin and Eosin and grading was done according to modified bloom and richardson gradingResults In breast cancer the expression of cKit observed to be high in malignant breast epithelium Expression of cKit decreased in the benign ductal epithelium and infiltrating duct cell carcinoma There is a significant increase in the expression of cKit in the stromal cells as the lesions progressed from benign to malignant phyllodes tumor Reduction in cKit expression in malignant breast lesions may suggest its carcinogenic role in the breastConclusion There is decrease in the expression of cKit was observed between benign ductal epithelium 92 and infiltrating duct cell carcinoma There is a significant increase in cKit expression observed in the stromal cells as the lesions progressed between benign 165 and malignant phyllodes 50Keywords CD117cKit Benign ductal epithelium malignant breast epithelium Haematoxylin and Eosin stainingnbsp
Authors and Affiliations
V. Manikanta, V. Siva Kota Reddy
Keywords
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- EP ID EP482743
- DOI 10.18231/2581-3706.2018.0014
- Views 110
- Downloads 0
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