Expression of the lingual antimicrobial peptide (LAP) in the bovine mammary gland with Staphylococcus aureus
Journal Title: Scientific Journal of Animal Science - Year 2016, Vol 5, Issue 2
Abstract
Mastitis is one of the most important infectious diseases in dairy cows around the world that causes great economic loses. To prevent and treat mastitis is important to understand the immunology of the mammary gland. Mammalian β-defensins are peptides of the local innate host defense with a potential as therapeutic agents. With the aim to better understand the role of these local antimicrobial peptides in the prevention of bovine mastitis, in the present study the mRNA expression of the lingual antimicrobial peptide (LAP)was determinedin 5 localizations of the bovine mammary gland with mastitis applying a quantitative real time PCR. The results showed that LAP was mainly expressed in the cisternal tissue with an average of 1.367 x 10 copies of mRNA, followed by 9.7 x 106copies in parenchyma, and the lowest expression was obtained streak canal. Therefore, LAPcould be involved in the local defense of the mammary gland since is overexpressed in these regions where S. aureusmainly invades and multiplies.
Authors and Affiliations
Alma Rossana Tamayo-Sosa*| Instituto de Investigaciones en Ciencias Veterinarias, Universidad Autónoma de Baja California, Mexicali, Baja California, Km 3.5 Carretera a San Felipe, Fraccionamiento Campestre S/N, México., Victor Manuel Del Villar-Pérez| Instituto de Investigaciones en Ciencias Veterinarias, Universidad Autónoma de Baja California, Mexicali, Baja California, Km 3.5 Carretera a San Felipe, Fraccionamiento Campestre S/N, México., Lourdes Carolina Pujol- Manríquez| Instituto de Investigaciones en Ciencias Veterinarias, Universidad Autónoma de Baja California, Mexicali, Baja California, Km 3.5 Carretera a San Felipe, Fraccionamiento Campestre S/N, México., Luis Tinoco-Gracia| Instituto de Investigaciones en Ciencias Veterinarias, Universidad Autónoma de Baja California, Mexicali, Baja California, Km 3.5 Carretera a San Felipe, Fraccionamiento Campestre S/N, México., Jose Angel Olivas-Valdez| Instituto de Investigaciones en Ciencias Veterinarias, Universidad Autónoma de Baja California, Mexicali, Baja California, Km 3.5 Carretera a San Felipe, Fraccionamiento Campestre S/N, México., Tonatiuh Melgarejo-García| Department of Human Nutrition, Kansas State University, Manhattan, KS, USA.
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- EP ID EP833
- DOI 10.14196/sjas.v5i2.2100
- Views 446
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