Extinction of emotional response as a novel approach of pharmacotherapy of anxiety disorders
Journal Title: Psychiatria Polska - Year 2009, Vol 43, Issue 6
Abstract
Studies on the neurobiological background of anxiety indicate that the patogenesis of anxiety may be related to the process of an extinction of aversive memories. It has been suggested that disruption of selective attention for emotional stimuli may confer the risk for mental disorders, such as phobias and post-traumatic stress disorder, PTSD. Differences in the effects of local neuronal and hormonal activities of the HPA axis on emotional memory formation, might underlie individual differences in the emotional reactivity. Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment of anxiety. Behavioural therapy of phobias and PTSD can be facilitated by D-cycloserine (the agonist at the glycine site of the NMDA receptor), ligands stimulating endogenous cannabinoid system and by gluocorticosteroids. Although all these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.
Authors and Affiliations
Małgorzata Lehner, Aleksandra Wisłowska-Stanek, Adam Płaźnik
Keywords
Related Articles
- EP ID EP118787
- DOI -
- Views 105
- Downloads 0
Neuroimmunologia choroby afektywnej dwubiegunowej
Previous neuroimmunological studies focused mostly on depression, regardless of its diagnostic category. In this paper, the studies on the immunological system in patients with bipolar affective illness, including manic...
Całkowita abstynencja czy redukcja szkód – różne strategie terapii uzależnienia od alkoholu w świetle badań i międzynarodowych zaleceń
Alcohol use is considered to be one of the major factors contributing to global health burden as well as social and economic harm. Only about 16% of alcohol dependent individuals enter addiction treatment programs in Pol...
Usefulness of the GEOPTE scale – self-rating scale of social cognition for persons suffering from schizophrenia
Summary Aim. To analyse psychometric value of the Polish version of the GEOPTE Scale, a self-rating scale measuring social cognition among persons suffering from schizophrenic psychoses. Method. Fifty patients with dia...
Psychoterapia jako dyskurs kulturowy
Streszczenie Nie sposób rozpatrywać psychoterapię bez odniesienia do kontekstu kulturowego. Kategorią szczególnie użyteczną dla rozumienia rozwoju tej dziedziny jest pojęcie dyskursu kulturowego. Refleksja nad ponad stu...
Iatrogenic influence of testosterone therapy among persons with Klinefelter Syndrome 87-95
Summary The purpose of this work is a presentation of cases of persons with Klinefelter Syndrome where, most probably – as a result of testosterone supplementation therapy, some aggressive behaviours occurred requirin...