Extracellular Vesicles in the Synovial Joint: Is there a Role in the Pathophysiology of Osteoarthritis?
Journal Title: Malaysian Orthopaedic Journal - Year 2019, Vol 13, Issue 1
Abstract
The role of extracellular vesicles (EV) in osteoarthritis has become the focus of much research. These vesicles were isolated from several cell types found in synovial joint including chondrocytes and synovium. As articular cartilage is an avascular tissue surrounded by synovial fluid, it is believed that EV might play a crucial role in the homeostasis of cartilage and also could hold key information in the pathogenesis of osteoarthritis. This is thought to be due to activation of pro-inflammatory factors leading to a catabolic state and degradation of cartilage. In addition, due to the nature of articular cartilage lacking neuronal innervation, knowledge of EV can contribute to identification of novel biomarkers in this debilitating condition. This can be either directly isolated from aspirate of synovial fluid or from peripheral blood. Finally, EVs are known to shuttle important signalling molecules which can be utilised as unique modality in transferring therapeutic compounds in a cell free manner.
Authors and Affiliations
Esa A, Connolly KD, Williams R, Archer CW
Keywords
Related Articles
- EP ID EP519538
- DOI 10.5704/MOJ.1903.012
- Views 131
- Downloads 0
CURRENT PROGRESS IN ORTHOPAEDICS
The content covers congenital, developmental and degenerative conditions, trauma, growth and infection related disorders, and clinically relevant basic scientific research. Congenital abnormalities affecting the limbs re...
The Use of PROSTALAC in Two-stage Reimplantation of Septic Total Knee and Hip Arthroplasty
The PROSTALAC (PROSThesis Antibiotic Loaded Acrylic Cement) functional spacer is made with antibiotic-loaded acrylic cement. We use it as an interim spacer in two-stage exchange arthroplasty in cases of infected total kn...
Normal Anterior Cruciate Ligament Laxity in the Malaysian Population
A study to determine average knee laxity in the Malaysian population and how it affects daily living was conducted at the University Malaya Medical Centre between January and April 2004. Fifty two male and 76 female subj...
Dynamic Hip Screw Fixation of Intertrochanteric Fractures of Femur: A Comparison of Outcome With and Without Using Traction Table
Intertrochanteric fracture of the femur is one of the common fractures in the elderly. Dynamic Hip Screw (DHS) fixation is the gold standard for treatment of intertrochanteric femoral fracture. Conventional methods of ac...
The Role of Polymerase Chain Reaction (PCR) in Diagnosis of Spine Tuberculosis after Pre-operative Anti-tuberculosis Treatment
Objective: The aim of this study was to evaluate the role of polymerase chain reaction (PCR) in the diagnosis of spinal tuberculosis after 2 weeks of preoperative anti-tuberculosis treatment and to compare PCR to the Löw...