Fabrication and Evaluation of Tinidazole Microbeads for Colon Targeting
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: The purpose of present investigation was to develop and evaluate multiparticulate system exploiting pH-sensitive property and specific biodegradability of calcium alginate microbeads, for colon- targeted delivery of Tinidazole for the treatment of amoebic colitis. Methods: Calcium alginate beads containing Tinidazole were prepared by ionotropic gelation technique followed by coating with Eudragit S100 using solvent evaporation method to obtain pH sensitive microbeads. Various formulation parameters were optimized which included concentration of sodium alginate (2% w/v), curing time (20 min) and concentration of pectin (1% w/ v). All the formulations were evaluated for surface morphology, particle size analysis, entrapment efficiency and in-vitro drug release in conditions simulating colonic fluid in the presence of rat caecal (2% w/v) content. Results: The average size of beads of optimized formulation (FT4) was found to be 998.73依5.12 毺 m with entrapment efficiency of 87.28依2.19 %. The invitro release of Eudragit S100 coated beads in presence of rat caecal content was found to be 70.73%依1.91% in 24 hours. Data of in-vitro release was fitted into Higuchi kinetics and Korsmeyer Peppas equation to explain release profile. The optimized formulation (FT4) showed zero order release. Conclusions: It is concluded that calcium alginate microbeads are the potential system for colon delivery of Tinidazole for chemotherapy of amoebic infection.
Prevalence of schistosome induced cercarial dermatitis in north of Iran
Objective: To investigate the level of people’s infection to cecarial dermatitis in Mazandaran Province(north of Iran), where is susceptible to this disease due to Mazandaran’s climate. Methods: The present descriptive s...
Pattern of Plasmodium-intestinal helminth co-infection among pregnant women in a high transmission zone of malaria in Nigeria
Objective: To investigate the co-infection of malaria and intestinal helminths and its burden among the pregnant women in Kwara State, Nigeria. Methods: Blood and faecal samples of pregnant women were randomly examined u...
Avian influenza in village chickens, its awareness and presence of potential risk practices among rural dwellers
Objective: To assess the presence of antibodies to the avian influenza virus H5 subtype in village chickens. Methods: A total of 480 sera samples were obtained from apparently healthy local chickens in four local governm...
Screening for mrsa as a preventive approach prior to nasotracheal intubation
Objective: This study was undertaken to determine the carriage of MRSA strains due to nasotracheal intubation into the lower respiratory tract where they can be a potential source of infection leading to high morbidity a...
An evaluation of National Anti-malaria Programme in a district of Karnataka, India
Objective: To assess the implementation of ongoing National Anti-Malaria Programme, malaria surveillance and the awareness of adult responsible respondents regarding mosquito borne diseases in Raichur District. Methods:...