Fabrication and Evaluation of Tinidazole Microbeads for Colon Targeting

Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0

Abstract

Objective: The purpose of present investigation was to develop and evaluate multiparticulate system exploiting pH-sensitive property and specific biodegradability of calcium alginate microbeads, for colon- targeted delivery of Tinidazole for the treatment of amoebic colitis. Methods: Calcium alginate beads containing Tinidazole were prepared by ionotropic gelation technique followed by coating with Eudragit S100 using solvent evaporation method to obtain pH sensitive microbeads. Various formulation parameters were optimized which included concentration of sodium alginate (2% w/v), curing time (20 min) and concentration of pectin (1% w/ v). All the formulations were evaluated for surface morphology, particle size analysis, entrapment efficiency and in-vitro drug release in conditions simulating colonic fluid in the presence of rat caecal (2% w/v) content. Results: The average size of beads of optimized formulation (FT4) was found to be 998.73依5.12 毺 m with entrapment efficiency of 87.28依2.19 %. The invitro release of Eudragit S100 coated beads in presence of rat caecal content was found to be 70.73%依1.91% in 24 hours. Data of in-vitro release was fitted into Higuchi kinetics and Korsmeyer Peppas equation to explain release profile. The optimized formulation (FT4) showed zero order release. Conclusions: It is concluded that calcium alginate microbeads are the potential system for colon delivery of Tinidazole for chemotherapy of amoebic infection.

Authors and Affiliations

Keywords

Related Articles

Survey on morphometric characteristic of different developmental stages of Dermacentor marginatus under laboratory conditions

Objective: To study the morphometric characteristics and biology of different developmental stages of Dermacentor marginatus (D. marginatus) under laboratory conditions. Methods: D. marginatus ticks were collected from s...

Variability of curcuminoid content and lack of correlation with cytotoxicity in ethanolic extracts from 20 accessions of Curcuma aeruginosa RoxB

Objective: To evaluate the contents of curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and the cytotoxic activity in ethanolic extracts of 20 Curcuma aeruginosa RoxB. (C. aeruginosa) accessions collec...

Lymphocystis in Indian oil sardine, Sardinella longiceps (Valenciennes 1847)

Objective: To analyse the prevalence and pathology of lymphocystis disease in Sardinella longiceps of three different landing centers in Tamil Nadu of southeast coast of India for a period of three years from January 201...

Salmonella spp. and risk factors for the contamination of slaughtered cattle carcass from a slaughterhouse of Bahir Dar Town, Ethiopia

Objective: To assess the prevalence of Salmonella species and associated factors from cattle carcasses in abattoir of Bahir Dar, Ethiopia. Methods: A cross-sectional study was conducted among slaughtered cattle carcass s...

Detection of gonorrhea among HIV infected patients by polymerase chain reaction

Objective: To determine the burden of gonorrhea among HIV patients using PCR technique. Methods: A cross sectional study was carried out in a HIV clinic of Sparsha Nepal from January to March, 2011. Standard microbiologi...

Download PDF file
  • EP ID EP233211
  • DOI 10.1016/S2222-1808(12)60151-0
  • Views 97
  • Downloads 0

How To Cite

(2012). Fabrication and Evaluation of Tinidazole Microbeads for Colon Targeting. Asian Pacific Journal of Tropical Disease, 2(0), 197-201. https://www.europub.co.uk/articles/-A-233211