Falciparum malaria associated changes in biochemical indices in children

Journal Title: Journal of Medical and Allied Sciences - Year 2017, Vol 7, Issue 1

Abstract

Metabolic disturbances associated with fluid and electrolyte imbalance, and changes in the synthetic functions of the liver are common compli-cations of malaria and are dependent on the degree of parasitemia. Packed cell volume (PCV), random blood glucose (RBG), total bilirubin (TB), total proteins (TP), albumin, serum electrolytes [sodium (Na+), potassium (K+), chloride (Cl-), bicarbonate (HCO3-), calcium (Ca2+), magnesium (Mg2+)] and anion gap (AG) were determined in fifty chil-dren with malaria aged between 1-15 years and thirty age matched apparently healthy children without malaria, using colorimetric and flame photometric methods. Data was analyzed using t-test at p < 0.05. The PCV, RBG, Na+, Mg2+, AG and TP were significantly lower and Ca2+ and TB higher in children with malaria compared to children without malaria. The serum Na+, K+, AG, TP and albumin were significantly lower and Ca2+, HCO3- and TB higher in children with severe malaria compared to those with mild malaria. Malaria and high parasite density is associated with perturbations in homeostasis of proteins and electrolytes and these may be implicated in the deleterious consequences associated with malaria in children.

Authors and Affiliations

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro

Keywords

Related Articles

A case of Bochdalek hernia in adult misdiagnosed as pulmonary tuberculosis

Bochdalek hernias are congenital defects resulting from the failure of posterolateral diaphragmatic foramina to fuse in utero. Usually it mani-fests in the neonatal period and occasionally in childhood. Symptomatic Bochd...

Effect of viral hepatitis E on maternal and fetal outcome

Viral hepatitis in pregnancy has been a subject of continuing interest. It is a major cause of enteric transmission of non A and non B hepatitis and is usually self limiting. However in pregnant women, it is more se-vere...

Unusual case of stroke in young

Thromboembolism is a rare extra-intestinal manifestation of inflammatory bowel disease. Thromboembolic event involving CNS in a case with in-flammatory bowel disease (IBD) is very rare & leads to increase in mor-tality....

Assessment of current burden of human rabies in Sir Ronald Ross Institute of Tropical and Communicable Diseases (SRRIT&CD) – Five year study

Human rabies has been still endemic in India. There are an increasing number of studies estimating the burden of human rabies, but the true incidence of the disease and endemicity were rarely reported in the literature....

Download PDF file
  • EP ID EP642957
  • DOI 10.5455/jmas.253029
  • Views 83
  • Downloads 0

How To Cite

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro (2017). Falciparum malaria associated changes in biochemical indices in children. Journal of Medical and Allied Sciences, 7(1), 29-33. https://www.europub.co.uk/articles/-A-642957