Fatal anaplastic lymphoma kinase positive anaplastic large cell lymphoma presenting with cutaneous lesions: A case report
Journal Title: Türkderm - Deri Hastalıkları ve Frengi Arşivi - Year 2017, Vol 51, Issue 2
Abstract
Anaplastic large-cell lymphoma (ALCL) is a CD30-positive non-Hodgkin lymphoma of T-cell origin. It comprises approximately 3% of all non- Hodgkin lymphomas. The skin may be the primary involvement site (primary cutaneous) or systemic ALCL may affect the skin as cutaneous metastasis. In systemic ALCL, 80-85% of cases exhibit anaplastic lymphoma kinase-1 (ALK). However, primary cutaneous ALCL is typically ALK-negative. The most important prognostic marker in systemic ALCL is the expression of ALK. Positive ALK is associated with a favourable prognosis in systemic ALCL. Here, we report a case of ALK-positive ALCL with a very aggressive clinical course. Our case was evaluated for brown-violaceous nodules appearing on the trunk, groin and arm for about 3-4 weeks. In a few days after the diagnosis of ALCL, the patient died because of sepsis which was thought to be associated with ALCL.
Authors and Affiliations
Funda Bapur Erduran, Esra Adışen, Nalan Akyürek, Mehmet Ali Gürer
Keywords
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- EP ID EP364974
- DOI 10.4274/turkderm.76148
- Views 98
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