Fatty acid composition in cerebral cortex, hippocampus and cerebellum in adult rats receiving salmon oil for 6 months
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 8, Issue 1
Abstract
[b]Introduction.[/b] Polyunsaturated fatty acids (PUFA) play an important role in the functioning of the brain, particularly in childhood and old age. The diet of pregnant mothers as well as very young children, affects the composition of fatty acids in childrens’ brains and suggests the question of whether a diet enriched in n-3 PUFA throughout adult life may result in elevated levels of PUFA n-3 in individual brain regions, and thus delay the aging process. [b]Objective.[/b] The purpose of this research was to establish the fatty acid composition in the cerebral cortex, hippocampus and cerebellum in adult rats receiving for 6 months salmon oil, which is a rich source of n-3 fatty acid. [b]Materials and method.[/b] 6-week-old rats were acclimatized for 2 weeks and then assigned into 2 groups (n=10): control and fish oil supplemented. Both control and supplemented animals were fed a semi-synthetic, isoenergetic diet that varied only in fat composition. The brain fatty acids profile was determined by gas-chromatography analysis. [b]Results. [/b]Rats fed the supplemented diet showed an increased level of 22:6n-3 and a decreased level of 20:4n-6 and C22:5n-6 in all brain regions when compared to the control group. Furthermore, there was an increase of all monounsaturated fatty acids (MUFA) only in the hippocampus of supplemented rats when compared to the control group. Saturated fatty acids (SFA) content was only slightly modified in the administered diets. [b]Conclusions[/b]. A diet rich fish oil can restore an adequate level of fatty acid in the aging brain.
Authors and Affiliations
Maciej Firląg, Piotr Ostaszewski, Bożena Balasinska
Keywords
Related Articles
- EP ID EP58805
- DOI -
- Views 166
- Downloads 0
Prevalence and risk factors for airway diseases in farmers--summary of results of the European Farmers' Project.
The aim of the European Farmers' Project was to determine prevalence and risk factors of respiratory diseases in farmers across Europe. A cross-sectional study in 7 centres was carried out. In the first stage of the stud...
Increasing role of arthropod bites in tularaemia transmission in Poland – case reports and diagnostic methods
The study describes four cases of tularaemia – one developed after contact with rabbits and three developed after an arthropod bite. Due to non-specific clinical symptoms, accurate diagnosis of tularaemia may be difficul...
Patient rights, risk, and responsibilities in the genetic era – a right to know, a right not to know, or a duty to know?
[b]Introduction and objective[/b]. As genetics tests ordered by physicians have implications not only for patients but also their relatives, they create a bioethical dilemma for both clinicians and patients. Especially w...
Effect of artificial and natural sweeteners on glucose and insulin in plasma of rats
Introduction: The role of artificial sweeteners in body-weight regulation is still unclear. Replacing sugar with low-calorie sweeteners is a common strategy for facilitating weight control. Whether using artificial sweet...
Fungal spores in four catholic churches in the metropolitan area of Monterrey, Nuevo León State, Mexico – First study
Introduction. About 500,000 species of fungi have been described to-date, although an estimated between 1 – 1.5 million species may occur. They have a wide distribution in nature, contributing to the decomposition of org...