FEASIBILITY OF KONDAGOGU GUM AS A CARRIER FOR COLON TARGETED DRUG DELIVERY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 7
Abstract
The present study has been undertaken to develop colon targeted drug delivery system for metoprolol succinate using kondagogu gum as a polymer. Matrix tablets of metoprolol were prepared using PVP K-30 as binder and kondagogu gum as a rate controlling polymer. The prepared tablets were evaluated for properties such as hardness, thickness, friability etc. The prepared tablets were coated with shellac as an enteric coat polymer and evaluated for enteric coat test. In vitro release studies of were carried out for 2 hrs in pH 1.2 HCl buffer, 3 hrs in pH 6.8 phosphate buffer and 7 hrs in the presence of 200 ml of simulated colonic fluid (SCF). In addition, kinetics of drug release from the matrices and stability of the tablet formulations were also investigated. Mathematical analysis of the release kinetics was done using PCP-V02 disso software and it showed that the nature of drug release from the matrix tablets has followed super case II transport which means drug release fro this system is by both diffusion and relaxation of polymer chain. FTIR and DSC studies have shown that no chemical interaction occurred between the drug and polymers used. The optimized formulation (F9) showed negligible difference in release mechanism as well as release kinetics when stability study was done for three months at 40±20 C and 75±5% RH.
Authors and Affiliations
N. Srujana , Ravi Valluru , Pramod Kumar , S. Vinay , Ajay Kulkarni
Keywords
Related Articles
- EP ID EP114093
- DOI -
- Views 101
- Downloads 0
SIGNALLING PATHWAY OF NADPH MEDIATED ROS-RNS IN DIABETIC NEPHROPATHY
Disorder of physiological signaling functions of reactive oxygen species (ROS) superoxide (ROS are chemically reactive molecules containing oxygen), hydrogen peroxide, reactive nitrogen species (RNS) nitric oxide and per...
MOLECULAR MODELING AND DRUG DISCOVERY OF POTENTIAL INHIBITORS FOR ANTICANCER TARGET GENE MELK (MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE)
Maternal embryonic leucine zipper kinase (MELK), a member of the AMP serine/threonine kinase family, exhibits multiple features consistent with the potential utility of this gene as an anticancer target. Reports show tha...
CENTRAL ANTINOCICEPTIVE EFFECT OF DIFFERENT EXTRACTS OF SARACA ASOCA SEEDS ASSESSED USING HOTPLATE AND TAIL IMMERSION METHODS
The stem bark of Ashoka (Saraca asoca) plant has been traditionally used for a number of therapeutic purposes including anti-inflammatory activities. It has been described in ancient Ayurvedic texts as an analgesic also...
IN VITRO ANTIBACTERIAL ACTIVITIES STUDY OF ALBIZZIA LEBBECK (L) BENTH LEAF EXTRACTS
To know the in vitro antibacterial activities of benzene, chloroform, acetone, ethyl acetate, ethanol and methanol extracts of the leaves of Albizzia lebbek(L) Benth. (Shirish), Family: Mimosaceae, present study was cond...
FORMULATION AND EVALUATION OF MICROSPONGE DRUG DELIVERY SYSTEM USING INDOMETHACIN
In the present study controlled release formulation of Indomethacin microsponges were prepared by using Eudragit RS 100, pH independent release retardant polymer and PVA, stabilizer or emulsifier. Microsponges were pre...