Features of the course of broncho-obstructive syndrome in young children depending on the level of vitamin D
Journal Title: Здоров`я дитини - Year 2017, Vol 12, Issue 6
Abstract
Background. Diseases of the respiratory tract, including broncho-obstructive syndrome (BOS), are common pathology in childhood. It is known that the incidence and severity of respiratory diseases correlates with the level of vitamin D (VD), which deficiency may contribute to the development of recurrent episodes of BOS in young children along with other risk factors, such as eosinophilia, family and individual allergy history. Materials and methods. 120 children aged 6 months to 3 years with the diagnosis of acute obstructive bronchitis were examined (I group — 60 children with episodic BOS, group II — 60 children with recurrent BOS). All children were evaluated for anamnesis, general clinical examination with assessment of severity of BOS according to the Seattle Children’s respiratory scoring tool. Laboratory studies included estimation of 25-hydroxyvitamin-D (25(OH)D) concentration in the blood serum using an electrochemiluminescence method on the Cobas e411 analyzer (serial number 1041-24, manufacturer Roche Diagnostics GmbH, Germany) and total calcium concentration in the blood serum according to the generally accepted methodology. Non-parametric statistical criteria were used for the analysis of the obtained data. The difference between compared indicators was considered as statistically significant at a rate of p < 0.05. Results. In children with recurrent BOS, unlike children with episodic one, the level of VD supplementation was significantly lower (p < 0.01). The course of BOS in children of group II was significantly more often associated with the development of respiratory failure syndrome in comparison to group I (p < 0.01). The disease was characterized by a more severe course in the presence of recurrent episodes of BOC in past. The mean serum 25(OH)D level in children of group I was 33 (28.1; 41.9) ng/ml and in group II — 13.68 (7.96; 19.51) ng/ml (U = 152.0; p < 0.01). Sufficient level of VD was more often noted in children of group I, while in the group II, children with VD deficiency prevailed. The inverse relationship between the level of VD and the incidence of BOS was found. The level of calcium in the blood serum in both groups was within the normal range. Conclusions. The development of recurrent episodes of BOS is associated with lower levels of 25(OH)D in the blood serum. The severe course of BOS is more common in children with recurrent episodes on the background of VD deficiency, which, however, is not accompanied by disturbances of calcium metabolism. An adequate level of VD is mostly provided by the sufficient level of its supplementation, especially in the first year of life. Thus, the course and frequency of episodes of BOS in young children depends on level VD.
Authors and Affiliations
Yu. K. Bolbot, T. A. Bordіj, K. K. Godjacka, N. M. Petrik, O. A. Litovchenko
Keywords
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- EP ID EP230728
- DOI 10.22141/2224-0551.12.6.2017.112838
- Views 75
- Downloads 0
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