Features of the inflammatory response in infants with congenital and acquired pneumonia

Journal Title: Здоров`я дитини - Year 2017, Vol 12, Issue 1

Abstract

Background. Congenital infection protection factors are proteins-cytokines, their formation and secretion occurs in response to the presence of the antigen in the body. Objective: to explore the features of the inflammatory response of newborns with congenital and acquired pneumonia in terms of interleukin (IL) 1β and 10. Materials and methods. Clinical and paraclinical examination of 69 term infants with pneumonia were performed. They underwent clinical and paraclinical studies (C-reactive protein (CRP), interleukin 1β and 10 content in the blood serum, X-ray examination of the chest). Results. It was found that the content of ІL-1β in children of group I and II significantly exceeded the indicators of the control group. However, the rate of ІL-1β in children from group I was significantly lower than in children of group II. In children from group II, who required artificial ventilation, IL-10 content was significantly higher compared to those, who did not need artificial ventilation. It was also determined the dependence of ­ІL-1β and IL-10 indicators on CRP levels — the higher the CRP, the lower the level of ІL-1β and IL-10. Evaluation of ІL-1β and ­IL-10 content depending on the localization of the inflammatory process in the lungs showed that with the proliferation of infiltrative changes in the lungs of children from group II, there was an increase in the level of ІL-1β and IL-10, and in children from group I — a reduction. Conclusions. The level of IL-1β in children of group I and II significantly exceeded the levels of the control group, and the IL-10 index — did not. However, the rate of IL-1β in children from group I was significantly lower than in children of group II. It was established the inverse correlation of IL-1β and IL-10 content with the severity of inflammation in the lungs and the level of CRP in the blood serum.

Authors and Affiliations

I. I. Reminna

Keywords

Related Articles

The Characteristic of Metabolic Changes at Insulin Resistance in Children with Primary Hypertension

In children with hypertension we identified various metabolic disorders and the role of insulin resistance in their development, as well as compensatory mechanisms of maintaining normoglycemia.

Eating behavior and quality of life in high school pupils in Lviv

Background. The negative dynamics of the health of the children population needs to increase attention to this problem, first of all — to provide an effective preventive component of medical care. Analyzing the reasons f...

Possibilities of Correction for Iron Deficiency and Intestinal Microbiocenosis Disorders in Children

Iron deficiencies and intestinal microbiocenosis disorders in children are the most urgent problems in pediatrics. The article presents the data of our own researches on the effectiveness of the correction for iron defic...

World experience on the diagnosis of interstitial diseases of the lungs in children (up-date 2017)

The article presents modern principles of classification, diagnosis and treatment of interstitial lungs diseases in children for the practice of pediatricians, family doctors, pediatric pulmonologists, thoracic surgeons,...

Status of child population health — the future of the country (part 1)

The article of the team of scientists of pediatricians and organizers of pediatric health care of Ukraine is devoted to the study of the main trends in the health status of children over last 22 years. The results of the...

Download PDF file
  • EP ID EP180073
  • DOI 10.22141/2224-0551.12.1.2017.95013
  • Views 122
  • Downloads 0

How To Cite

I. I. Reminna (2017). Features of the inflammatory response in infants with congenital and acquired pneumonia. Здоров`я дитини, 12(1), 24-28. https://www.europub.co.uk/articles/-A-180073