Features of Treatment of Patients Infected with Hepatitis C Virus Genotypes 1 And 4 by Direct-Acting Antiviral Drugs
Journal Title: Гастроентерологія - Year 2016, Vol 3, Issue 61
Abstract
Hepatitis C is an urgent problem today because of the low efficiency and a significant number of side effects of conventional therapy. The problem of the treatment of hepatitis C virus (HCV) genotypes 1 and 4 is particularly acute, as they are the most resistant to traditional treatment regimens. The solution to this problem, apparently, is the use of a relatively new group of direct-acting antiviral drugs (DAAD). This article discusses the various schemes of treatment with these products, their mechanism of action and effectiveness, as well as compares two of the most effective and promising DAAD available on the global market — Harvoni (sofosbuvir/ledipasvir) and Viekira Pak (ombitasvir/paritaprevir/ritonavir + dasabuvir). Current guidelines of the European Association for the Study of the Liver (EASL), American Association for the Study of Liver Diseases (AASLD) and the Canadian Association for the Study of the Liver (CASL) on the treatment of patients with HCV genotypes 1 and 4 are also compared.
Authors and Affiliations
V. P. Shypulin, A. A. Kuzminets
Keywords
Related Articles
- EP ID EP210105
- DOI 10.22141/2308-2097.3.61.2016.79160
- Views 70
- Downloads 0
State of Motor-Evacuation Function of the Stomach According to 13C-Octanoate Breath Test in Patients with Gastroesophageal Reflux Disease
We examined 58 patients with erosive form of gastroesophageal reflux disease and 10 healthy volunteers. All patients underwent fibrogastroduodenoscopy, 24 hour pH monitoring in the lower third of esophagus, 13C-octanoate...
Activity of Plasma Proteolysis Indicators and Their Correction in Patients with Chronic Obstructive Pulmonary Disease Associated with Chronic Pancreatitis
We have investigated the changes in the activity of plasma proteolysis indicators in patients with chronic obstructive pulmonary disease, associated with chronic pancreatitis, in the dynamics of treatment.
Minimally invasive technologies in the treatment of ulcerative pylorobulbar stenosis
Background. The purpose was to develop approaches to minimally invasive treatment of patients with ulcerative pyloroduodenal stenosis. Materials and methods. In 2015–2018, at the department of surgery of the digestive or...
Chronic inflammatory bowel diseases: epidemiological features in Ukraine
Background. The number of registered patients with inflammatory bowel diseases (IBD) that is characterized by systemic manifestations and polymorbidal course is increasing nowadays. IBD, which include ulcerative colitis...
Breath Tests Application in Order to Improve the Outcomes of Treatment for Celiac Disease
The article presents data from an own study on modern opportunities to improve the effectiveness of treatment of patients with celiac disease (n = 41). All patients were on a gluten-free diet, nonetheless effectiveness o...