Fine-needle aspiration cytology of granulocytic sarcoma: A cytomorphologic analysis
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Granulocytic sarcoma is a rare extramedullary tumor comprising of immature myeloid cells in an extramedullary site which is commonly found with myeloid leukemia acute or chronic or occasionally with chronic myeloproliferaive disorders or myelodysplastic syndrome GS may also be the initial manifestation of leukemia Because of the diverse clinical presentation differentiation of Granulocytic sarcoma GS from malignant lymphomas Non Hodgkin39s lymphoma or Hodgkins lymphoma extramedullary hematopoiesis poorly differentiated carcinoma and infections is very important for cytopathologistMaterials and Methods A retrospective study of total 16 cases of GS diagnosed by FNAC 14 FNAs and 2 pleural effusion fluid specimen was done Cytology smears were examined for cytomorphology in conjunction with clinical details Depending upon the population of the cells present on the smears GS was categorized as blastic immature or mature GSResults The age of patients ranged from 8 years to 50 years with male dominance 10 males and 6 femalesThe most commonest site of aspiration was subcutaneous or soft tissue 9 cases followed by lymphnodes 4 cases and breast 1 case 2 cases of GS involving pleural fluid were also included A detailed history clinical examination and relevant investigations of patients showed that GS was secondary to acute myeloid leukemia AML in 6 patients was secondary to chronic myeloid leukemia CML in 3 patients and was secondary to juvenile myelomonocytic leukemia JMNL in one patients 6 patients were presented with concurrent myeloproliferative disorder AML in 4 patients and CMLCP in 2 patientsDepending upon the population of the cells present on the smears GS was categorized as blastic GS 7 aspirates immature GS 3 aspirates and mature GS 6 aspiratesConclusion FNAC plays important role in diagnosis of GS GS should be included in the diagnosis of undifferentiated neoplasm of the soft tissue or lymph nodes even in patients with no clinical suspicion of leukemia Detailed patients clinical history along with careful morphologic evaluation for granulocytic cell identification should helps to reach a definitive diagnosisKeywords Cytomorphology Fine Needle Aspiration Cytology Granulocytic Sarcoma
Authors and Affiliations
Chetan M. Dharaiya, Trupti S. Patel, Majal G. Shah, Jahnavi S. Gandhi
Keywords
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- EP ID EP473177
- DOI 10.18231/2394-6792.2018.0006
- Views 66
- Downloads 0
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