Fixed Dose Combination of Voglibose & Repaglinide in the Management of Postprandial Hyperglycemia in Indian Subjects
Journal Title: Global Journal of Obesity, Diabetes and Metabolic Syndrome - Year 2017, Vol 4, Issue 3
Abstract
To evaluate the efficacy and tolerability of fixed dose combination of voglibose and repaglinide in postprandial hyperglycemia (PPHG) in Indian subjects. A non-randomized, open labeled, non-comparative, single-centric, study was conducted in total of 20 type 2 diabetes mellitus (T2DM) patients (9 men and 11 women, mean age 69.07 ± 3.495 years). Each patient was administered a fixed dose combination of voglibose 0.3mg and repaglinide 0.5/1mg three times a day, just before each meal for 30 days. Fasting blood glucose (FBG) and postprandial blood glucose (PPBG) was performed at baseline and at the end of study as assessment tools. At the end of study data was extractable only in 15 patients because 5 patient dropped out as they did not turn up for follow up at day 30.Postprandial blood glucose reduced significantly {-61.67mg/dl (95% confidence interval -76.79 to -46.54 p<0.0001)} from baseline at day 30. Also a significant reduction (p<0.0001) was found with FBG {-42.13mg/dl (Confidence interval -61.25 to -23.02 P value <0.0001)} at end of day 30. There were no adverse events reported including hypoglycemia. Voglibose and Repaglinide combination was effective and safe for the management of PPHG in T2DM patients.
Authors and Affiliations
Faruqui Arif
Keywords
Related Articles
- EP ID EP343908
- DOI 10.17352/2455-8583.000026
- Views 101
- Downloads 0
Role of Micro-And Macro-Nutrients in Obesity Onset
The incidence of obesity has been increasing exponentially for the last 30 years, and it is posing a major health issue in the US and worldwide. The 2015 reports by the World Health Organization (WHO) and the Center for...
Transient Hypoparathyroidism in Diabetic Ketoacidosis
Introduction: Diabetic ketoacidosispatients frequently develop a constellation of electrolyte disorders. These patientsare markedly potassium-, magnesium- and phosphate-depleted, but hypocalcemia due to transient hypopar...
Behavioral therapy in diabetes mellitus and obesity
In Weimar, on the wall of Albert Schweitzer Museum, there is a memorial tablet which says: “The purpose of our life is to serve, to show solidarity and helpfulness.” The humanist medical doctor, theologian, philosopher,...
Breath Acetone as Biomarker for Lipid Oxidation and Early Ketone Detection
Former ketone studies, including ketoacidosis (KAD), fasting ketosis (FK), nutritional ketosis (NK), and exercis-eaffected ketosis have brought great advances to the field of ketones. In the present work, blood, urine an...
The Metabolic Syndrome in Hispanics – The Role of Inflammation
We report clinical and molecular mechanisms relating the pro-inflammatory and anti-inflammatory process in the development of the components of the metabolic syndrome, emphasizing the cardiovascular problems developed in...