Fixed drug eruption to cetirizine – role of patch testing
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2016, Vol 2, Issue 3
Abstract
Antihistamines are prescribed for a wide variety of disorders like urticaria, eczema, allergies and infestations. Adverse reactions due to them is unusual and the incidence of fixed drug eruption is scarce. They are characterized by a sudden onset of edematous, erythematous plaques appearing at the same sites following an oral provocation with the drug and is proposed to be due to the epidermal CD8+ T cells resident at the sites of these residual post inflammatory hyper pigmented macules. Antihistamines sharing a similar chemical structure have an increased likelihood of showing cross reactions and a patch test based evaluation can be carried out to deduce the offending drugs, cross reactions and alternative medications.
Authors and Affiliations
Sonia Raghukumar, Ravikumar BC
Keywords
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