Folate Up-to-date
Journal Title: Journal of Analytical Bio-Science - Year 2012, Vol 35, Issue 4
Abstract
Folate is one of essential vitamin, and vital to normal cell growth and DNA synthesis. Folate deficiencies lead to megaloblastic anemia and ultimately to severe neurological problems. Folate concentration can be different depending on methods used for assessments. Therefore, there are needs for international reference materials as well as universal cutoffs of the deficiencies so that population prevalences of the deficiency can be properly determined and compared. Recently, World Health Organization (WHO) International Standard (IS) 03/178 and Standard Reference Material (SRM) 1955 were launched as reference materials for serum folate. These materials were determined using isotope dilution liquid chromatography-tandem mass spectrometry (LC/MS/MS). As a consequence, the restandardized Access folate assay, with WHO IS 03/178, is upcoming. In addition, WHO Technical Consultation defined the cutoffs for folate deficiencies.
Authors and Affiliations
Kazuko Nishimura, Kazuo Mori
Keywords
Related Articles
- EP ID EP108891
- DOI -
- Views 63
- Downloads 0
Development of THP assay and clinical applications
Tamm-Horsfall protein (uromodulin) is the most abundant glycoprotein in human urine. It is synthesized exclusively in the thick ascending limb of the loop of Henle. Its biological function remains unclear. Qualitative an...
Effect on Quality of Life of a Lentinus edodes mycelia-enriched diet (L･E･M®) in patients with terminal cancer
Purpose: It is important to offer the highest possible quality of life (QOL) for terminal cancer patients in palliative medicine. It was examined whether Lentinus edodes mycelia (L･E･M®) -containing diet (CORELEM®) was e...
Abnormalities of carnitine metabolism in human diseases
Recently many new diseases involving abnormalities of the carnitine metabolism have been reported. It is very important for every one in the medical field to understand the role carnitine plays in such pathological condi...
Blood clotting time tests using an automated coagulation analyzer−ACL TOP series, STACIA−
The hemostatic mechanism is very important for achieving a vital self-defense. The blood-clotting-time is the test to examine coagulation reaction, including both the extrinsic and intrinsic coagulation systems, whether...
MPO release reaction against activated neutrophils
Against infection, neutrophils form phagosomes in which microorganisms are absorbed by phagocytosis. Then, from the azurophilic granules of neutrophils, Myeloperoxidase (MPO) and granule components are released. In this...