Follow up of Drug-Resistant Pulmonary Tuberculosis Patients in a DRTB Center in First Fifteen Months of Treatment
Journal Title: Journal of Communicable Diseases - Year 2017, Vol 49, Issue 3
Abstract
Background and Objective: Multidrug-resistant tuberculosis (MDR-TB) is defined as resistant to both INH and Rifampicin with or without resistance to other first-line antitubercular drugs. The aim of the study was to assess the sputum culture conversion rate during first 12 months of treatment in drug-resistant TB patients, to assess the impact of comorbid illnesses and other factors on culture conversion by following up the patients up to 15 months after initiation of treatment. Materials and Methods: This was a prospective study comprising of 142 diagnosed patients of drug-resistant TB admitted in this center from April 2014 to March 2015 for treatment initiation, excluding extrapulmonary TB and already diagnosed extensively drug-resistant tuberculosis (XDR-TB). After pretreatment evaluation, standard second-line antitubercular drug (CAT-IV) was started. Patients were followed up in first 15 months of treatment. Results of sputum culture for mycobacteria at 3rd, 4th, 5th, 6th, 7th, 9th and 12th months after treatment initiation were analyzed. Results: Sputum culture for mycobacteria was converted negative within one year in 95 cases (67%); whereas 18 patients died during follow up, 27 defaulted and 2 patients switched over to CAT-V after development of extended drug-resistance during follow up. Conclusion: Though drug-resistant tuberculosis (DRTB) is one of the biggest challenges to public health program in India, treatment with standardized second-line drugs under RNTCP have a favorable outcome as indicated by sputum culture conversion of as many as 67% of patients within one year in this study.
Authors and Affiliations
Dr. Saurav Kar
Keywords
Related Articles
- EP ID EP225919
- DOI 10.24321/0019.5138.201716
- Views 170
- Downloads 0
Contamination Status of Hospitals and Health Care Centers by Rodents (Rodentia: Muridae) in Iran
Introduction: Rats are considered as an important potential reservoir for some zoonotic diseases and have an important role in the transmission and spreading them. This research was performed with the purpose of studying...
An Epidemiological Study to Assess the Environmental and Socio-Cultural Determinants of Malaria in Coastal Karnataka
Background: India has grappled with the problem of malaria since many decades. Moreover, Udupi district contributes 13% of malaria cases to Karnataka making it a significant public health concern. Objectives: To explore...
A New Approach to Evaluate Quality Adjusted Life Years Using Proxy Utility Function - An Application to HIV/ AIDS Data
Estimation of Quality Adjusted Life Years (QALYs) is pivotal towards economic evaluation and cost-effectiveness analysis of medical interventions. Most of the methods developed till date for calculating QALYs are based o...
An Epidemiological Study of Hepatitis Outbreak in Cuttack City, Odisha
Hepatitis is a highly infectious disease caused by a number of viruses. A study was undertaken in a ward of Cuttack City, where suddenly a number of cases of Jaundice reported. A team from the departments of Community Me...
Wellems TE, Hayton K, Fairhurst RM. The impact of malaria parasitism: from corpuscles to communities. The Journal of Clinical Investigation 2009; 119(9): 2496-505
The National Society of India for Malaria and Other Mosquito-Borne Diseases was registered on Sept. 20, 1950 under Societies Registration Act XXI of 1860. The objects and purposes of the Society were (i) to advance knowl...