Forgotten Effect of Hydroxychloroquine in the Sjogren’s Syndrome: Ototoxicity
Journal Title: Journal of Ankara University Faculty of Medicine - Year 2021, Vol 74, Issue 1
Abstract
Objectives: Sjogren’s syndrome is a chronic, autoimmune and inflammatory disease. Sensorineural hearing loss is reported in ear involvement but the cause of this hearing loss is not known yet. Hydroxychloroquine has been long known to have ototoxic effects and it is often used in Sjogren treatment. In our study, we tried to explain the correlation of hearing loss in Sjogren with hydroxychloroquine use. Materials and Methods: A prospective control study was designed and Sjogren syndrome patients were divided into two. Group 1 consist of 20 patients with drug usage. Group 2 consist of 15 patients without drug usage. Pure tone audiometric examination was done to all patients. Results were analyzed. Results: There was not any statistically significant difference between the groups for either ear at 250 Hz, 500 Hz, 1000 Hz and 2000 Hz in the audiograph (p>0.05). There was a statistically significant difference at 4000 Hz in the left ear and 8000 Hz in the right ear and at 10,000 Hz in both ears (p<0.05). There was not any statistical significance at 4000 Hz in the right ear and at 8000 Hz in the left ear (p>0.05). Conclusion: Sensorineural hearing loss can occur particularly at high frequencies in the Sjogren’s syndrome. This can be related to the duration of the disease or maybe it can occur due to hydroxychloroquine that is commonly used in treatment and known to be ototoxic. In our study, it was found that this drug had an impact on hearing loss. As the drug can accelerate the hearing loss that is already anticipated, it can also be completely responsible for the hearing loss by itself.
Authors and Affiliations
Yüce İslamoğlu, Muharrem Gerçeker
Keywords
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- DOI 10.4274/atfm.galenos.2020.68442
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