FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE
Journal Title: Universal Journal of Pharmaceutical Research - Year 2018, Vol 3, Issue 6
Abstract
Terbinafine is a broad spectrum antifungal drug. The aim of present study was to develop topical nano emulgel of terbinafine using carbopol 934 as a gelling agent. The objective behind the formulation was to avoid dosing frequency and to increase the stability and bioavailability by avoiding the first pass metabolism. The formulations were prepared by using oleic acid, carbopol 934, span 20, propylene glycol in different ratios and analyzed by pseudo tertiary phase diagram. All the five prepared nano emulgel formulations have shown satisfactory physiochemical properties. The stability and particle size is been determined by zeta potential. The highest drug release 82.38 %was found in formulations of batch F4, which follows non-fickian mechanism. The studies showed that changing the concentration of oil, surfactant, co surfactant and double distilled water as aqueous phase has an impact on the behavior and thermodynamic stability of the nanoemulsion. Study concludes that of Terbinafine can be deliverered effectively by nano emulgel formulations.
Authors and Affiliations
Sonia Paliwal, Gurleen Kaur
Keywords
Related Articles
- EP ID EP36502
- DOI https://doi.org/10.22270/ujpr.v3i6.223
- Views 467
- Downloads 0
AWARENESS AMONGST YOUTH ABOUT USE AND ABUSE OF STEROIDS IN KARACHI, PAKISTAN
Aim of present study was to analyze awareness regarding the use of steroids in the youth studying health sciences. A descriptive, observational study was conducted from September to December 2017. Youth studying health...
INVESTIGATING THE OBSTACLES OF IMPLEMENTING HEALTH INFORMATION SYSTEMS FROM VIEWPOINT OF PERSONNEL OF MEHRIZ HEALTHCARE SYSTEM IN 2017
Health centers have a special significance as one of main organizations of providing services and first line of access to services for people. These centers severely require using various means of information systems due...
TABLET GRANULATION: CURRENT SCENARIO AND RECENT ADVANCES
Granulation is a size enlargement process, in fine or coarse particles converted into physically stronger and larger agglomerates having good flow property, better compression characteristics and uniformity, prevent segr...
Editorial..
It is great honor and privilege for me to be appointed as Member - Editorial Board, Universal Journal of Pharmaceutical Research (UJPR). My heartiest salutations to Prof. Dr. Kapil Kumar, Editor-in-Chief and the other bo...
FABRICATION AND EVALUATION OF HERBAL OINTMENT FORMULATIONS OF MORINGA OLIFERA FOR TOPICAL DELIVERY
Traditional medicine is an important source of potentially useful new compounds for the development of chemotherapeutic agents. Moringa oleifera Lam. is a multipurpose and exceptionally nutritious vegetable tree with a v...