FORMULATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 2
Abstract
The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration superdisintigrents.Fast dissolving tablets of Aceclofenac were prepared by wet granulation technique using sodium starch glycolate together with Polyplasdone xl-10 as superdisintegrants.The porous granules were then compressed in to tablets. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and Dispersion time. All the formulations showed low weight variation with dispersion time less than 90 seconds and rapid in vitro dissolution. The drug content of all the formulations was within the acceptable limits. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that fast dissolving tablets with improved Aceclofenac dissolution could be prepared by wet granulation of tablet. The dispersion time and dissolution parameter (t50% andt80%) decreased with increasing the concentration of Polyplasdone xl-10.
Authors and Affiliations
Siraj Shaikh , Nazim Sayyed , Pravin Gomase , Afsar Shaikh , Majaz Quazi
Keywords
Related Articles
- EP ID EP134960
- DOI -
- Views 458
- Downloads 0
THERAPEUTIC STRATEGIES FOR THE TREATMENT OF PERIODONTITIS
Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by groups of specific microorganisms. Aggressive forms of periodontitis can be localized or generalized. The concept that localized p...
MANAGEMENT OF HYPERLIPIDAEMIA (MEDO ROGA) IN AYURVEDA – A REVIEW
Hyperlipidemia, hyperlipoproteinemia, or hyperlipidaemia (Medo Roga) is the condition of abnormally elevated level of any or all lipids and/or lipoproteins in the blood. It is the most common form of dyslipidaemia (whic...
PHARMACOGNOSTICAL STANDARDIZATION AND ANTIMICROBIAL ACTIVITY OF LEAVES OF SYZYGIUM CUMINI (LINN.) FROM VARIOUS REGION OF NORTH INDIA
Syzygium cumini is one of the widely used medicinal plants in the treatment of various diseases in particular diabetes. In present investigation, the pharmacognostic study of Syzygium cumini leaf is carried out from diff...
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ELETRIPTAN IN ELETRIPTAN HYDROBROMIDE ORALLY DISINTEGRATING TABLETS
A simple, precise, rapid and accurate stability indicating reverse phase high performance liquid chromatography has been developed and validated for the estimation of Eletriptan Hydrobromide in tablet dosage form. Separa...
STUDY ON THE EFFECT OF GRAPE SEED PROANTHOCYANIDINS ON ADIPOCYTOKINE RECEPTORS IN DIET INDUCED FATTY LIVER DISEASE
Fatty liver is the hepatic component of the metabolic syndrome. Compelling evidence demonstrate that cytokines produced by the adipocytes play a major role in the pathogenesis of fatty liver disease. This study investiga...