FORMULATION AND EVALUATION OF FAST DISSOLVING SUBLINGUAL FILM OF ATORVASTATIN CALCIUM
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2020, Vol 7, Issue 11
Abstract
Atorvastatin calcium (ATC) is the most effective and best tolerated agent for treating Coronary heart disease. ATC is unstable and at risk to heat, light, and moisture when packed in the form of tablets, powders, granules, or within capsules. In acidic environment it degrades into corresponding lactone. This instability of ATC leading to poor solubility is the main cause for low bioavailability of the drug after oral administration as the absolute bioavailability of ATC is only 14%. Therefore, aim of the research is to improve the oral bioavailability by formulating it into a fast dissolving sublingual film. Formulations were prepared composed of HPMC E15, HPMC K15M and Pectin as a film forming agent; Crospovidone, Sodium starch glycolate, and Croscarmellose sodium as a superdisintegrating agent; Polyethylene glycol as a plasticizer; citric acid as a saliva stimulating agent; mannitol as a sweetening agent; methanol and water as a solvent. Different film formulations of Atorvastatin calcium were prepared by using HPMC E15, HPMC K15M, Pectin, Crospovidone. Different formulations were prepared by varying concentration of (polymers and disintegrating agent) ratio by solvent casting method. The compatibility study of drug and excipients was performed by IR study and no interaction was found. The prepared films were clear, transparent and smooth surface. The percentage moisture uptake and percentage moisture loss were found to be high for the patches formulated with HPMC E15 and HPMC K15M when compared to the film formulated with pectin. Folding endurance of HPMC E15 and HPMC K15M containing films were found to be higher than the other films which might be due to the nature of the polymers. The formulations F1-F3 showed a better in vitro disintegration time (13-14 seconds), when compared to the other formulations. Optimized batch F1 containing containing hydroxy propyl methyl cellulose (500mg) and crospovidone(30mg) showed in vitro drug release (98.33%) within 6 minutes. The formulations F1 showed a better in- vitro permeation study profile (95.61 within 11minute), when compared to the other formulations. Keywords: Atorvastatin calcium, Coronary heart disease, bioavailability, fast dissolving sublingual film, film forming agent, in vitro dissolution study
Authors and Affiliations
G. Gnanarajan* , Garima Thapliyal,
Keywords
Related Articles
- EP ID EP690377
- DOI http://doi.org/10.5281/zenodo.4291662
- Views 258
- Downloads 0
HERBAL APPROACH FOR TREATMENT OF OBESITY – A REVIEW
Obesity is termed as “New World Syndrom” and considered as major health problem by WHO. It is associated with excessive fat accumulation in the body and measured by BMI [Body mass index]. It is caused by imbalance betwee...
FORMULATION AND EVALUATION OF TIME DEPENDENDT RELEASE OF MONTELUKAST TABLETS BY USING MINI TABLET TECHNOLOGY
Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma, chronic asthma attacks and to relive symptoms of seasonal allergies. The main drawback of conventional Montelukast for...
FREQUENCY OF RISK FACTORS OF STROKE IN PATIENTS PRESENTING TO PUBLIC SECTOR HOSPITALS OF LAHORE
Stroke also called as Cerebrovascular accident is a syndrome of rapid onset of cerebral deficit (usually focal) lasting >24 h or leading to death, with no cause apparent other than a vascular one. It is currently the thi...
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-CYCLIC AMINE BENZOTHIAZOLE DERIVATIVES
The synthesis of a new series of 2-(cyclic amine)-1, 3-benzothiazole derivatives were synthesized in satisfactory yield and evaluated for their anti-microbial activities. 2-(cyclic amine)-1, 3-benzothiazoles were synthes...
PATTERN OF PSYCHIATRIC CO-MORBIDITY IN CHILDREN, AN EPIDEMIOLOGICAL STUDY, AT SIR C. J. INSTITUTE OF PSYCHIATRY, HYDERABAD.
Background: According to the World Health Organization (WHO), now a day’s mental health disorders are the leading causes of disability worldwide. Most of the psychiatric disorders start in child hood and adolescent. In g...