FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY OF CEFOTAXIME USING RAFT FORMING APPROACH
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 4
Abstract
The cefotaxime is a broad-spectrum cephalosporin antibiotic. It is mainly used in the treatment of bacterial infections. Cefotaxime is a suitable candidate for controlled release administration due to its short elimination time 1 hour. The main aim of the present investigation is to increase the gastric residence time by preparing floating drug delivery by using raft forming approach thereby improving bioavailability. The prepared Cefotaxime floating drug delivery by using raft forming approach were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, total floating time, In-vitro dissolution studies and buoyancy lag time. Floating tablets were formulated using direct compression technique. Various polymers are used in the formulation they Microcrystalline cellulose used as binder, HPMC K15M, Guargum used as hydrophilic polymers, Chitosan, Sodium bicarbonate was incorporated as an effervescent substance, Sodium alginate used as viscous gel forming agent, Magnesium streate used as lubrication, talc was used as diluent. The formulated Cefotaxime tablet to be evaluated the following parameters as follow Weight variation (mg), Hardness, Thickness, Friability, Drug content uniformity, Floating lag time, the in vitro cumulative amount of drug released was shown the F7 is 99.28% within 45 minutes the comparative studies with marketed formulations F7 show the better results.
Authors and Affiliations
Ramesh Yerikala
Keywords
Related Articles
- EP ID EP293857
- DOI 10.22270/jddt.v7i4.1477
- Views 121
- Downloads 0
PHYSICOCHEMICAL PROPERTIES OF SOME PAEDIATRIC AND ADULT PRODUCTS OF DIHYDROARTEMISININ-PIPERAQUINE ANTIMALARIAL MARKETED IN NIGERIA
The quality indices of dihydroartemisinin–piperaquine (DP) pediatric and adult (DPP and DPA) formulations of antimalarial were assessed. Moisture content, viscosity, total solid for four (DPP) products along with weight...
FLAXSEEDS AND AJWAIN FOR PRIMARY HYPERLIPIDEMIA
Research work was single blind placebo-controlled, conducted at General Hospital, Lahore, Pakistan conducted from NOVEMBER 2015 to JANUARY 2016. 75 diagnosed primary hyperlipidemic patients were selected with age range...
Formulation and development of fast dissolving oral film of a poorly soluble drug, frusemide with improved drug loading using mixed solvency concept and its evaluation
The aim of the present research work is to explore the application of mixed solvency concept to formulate and develop a fast dissolving oral film of furosemide with improved drug loading. In the present study, poorly sol...
Study on Drug Prescribing Pattern in Dengue Patients in a Tertiary Care Hospital – A tool to teach Clinical Pharmacology
Introduction and Aim: Dengue fever (DF) is the most common arboviral infection of mankind gaining global attention. Data about drug usage patterns in DF in India are lacking.The present study was undertaken to analyze dr...
EVALUATION OF ANTIDIABETIC ACTIVITY OF FRUITS OF WITHAHNIA COAGULANS IN STREPTOZOCIN INDUCED DIABETIC RATS
In past there have been many medicinal plants, which have been used in traditional medicines for their antihyperglycemic properties without any scientific support and pharmacological evidence. The aqueous extract of With...