Formulation and Evaluation of Microparticles of Metronidazole
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
In the present study it was aimed to formulate delayed release Metronidazole microparticles, which will have enteric as well as sustained release properties. For the preparation of Metronidazole microparticles CAP, HPMCP, Eudragit L-100 and Eudragit S-100 were used as coating materials. Among the prepared microparticles the best formulation is reported by in-vitro release studies. Microparticles of Metronidazole were prepared using cellulose acetate phthalate as the retardant polymer by emulsion-solvent evaporation method. The microparticles formed were collected by filtration. They were evaluated for morphology, melting point, size distribution, drug content and percentage drug entrapped, flow property, in-vitro drug release and comparative drug release studies with commercial dosage forms. Drug content and percentage of drug entrapment were found to good in all the batches, as the entrapment values were not less than 85%. All batches of microparticles were found to have enteric release property as it was expected. The drug release from all batches of microparticles was found to be concentration dependent (first order release kinetics).The mechanism of drug release was found to be erosion as it was revealed by (1-Mt/M) 1/3 versus time plots. Comparative drug release study revealed that the formulated product (microparticles) have more sustained effect than the marketed product.
Authors and Affiliations
J. Ravi Kumar Reddy , K. Gnanaprakash , A. V. Badarinath , C. Madhu Sudhana Reddy
Keywords
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