FORMULATION AND EVALUATION OF MONTELUKAST SODIUM PULSATILE DRUG DELIVERY SYSTEM BY CORE IN CUP METHOD
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 1
Abstract
The aim of present study is to Formulate and Evaluate Montelukast Sodium Pulsatile Drug Delivery system by Core in Cup method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 7 hours. The basic design of the system consists of a rapid release core and controlled release coat. A combination of Hydroxy Propyl Methyl Cellulose and Ethyl Cellulose was used as a coating material for the tablet. Ten formulations (F1-F10) of the core were prepared by using CCS, SSG and CP as disintegrants in different proportions (5, 7.5 and 10%) to study the effect of variable concentrations of these on the characteristics of the formulation. Core blend was evaluated for Flow properties Hardness, Thickness, Friability and invitro drug release. Among the Ten formulations F9 containing CP (7.5%) as disintegrant showed a better drug release of 100% over 45minutes was selected .The core was coated with HPMC and EC with different polymer ratios (P1F9- P5F9). Among these P2F9 was optimized based on the lag time and percent of drug release (10.2% of drug release in 7 hours).
Authors and Affiliations
D. Bhavani , CH. S. Vijaya Vani , V. Uma Maheshwar Rao
Keywords
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