FORMULATION AND EVALUATION OF NASAL IN SITU GEL OF RIZATRIPTAN BENZOATE
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 2
Abstract
In situ gel drug delivery systems are in elucidation form prior to supervision but once administered, endure gelation in situ, to form a gel. In the current revise nasal in situ gel of rizatriptan Benzoate was primed for the cure of nasal infections to give sustained release of drug and to attain site specific action. Carbopol was use as a pH triggered polymer Different formulations were prepared by varying the concentrations of Carbopo with Hydroxylpropyl Methylcellulose (HPMC). These formulations were evaluated for parameters like drug excipient compatibility, pH, drug content, gelation temperature, viscosity, in vitro drug release, mucoadhesion, ex vivo permeation and stability studies. FTIR study exposed that there was no interface between drug and polymer. pH of all the formulations were initiate to be in the vary of 5.4-6.2 and the drug substance for all the prepared formulations was initiate to be in the assortment of 94%-99%. The results of in vitro drug release and mucoadhesive strength indicated that the optimized formulation F5 and is the most successful formulations of the study, exhibited a sustained drug release of in 87.7% in 7 hours. mucoadhesive strength of 2024.64 and 3267.76 dyne/cm2. From the results it is fulfilled that rizatriptan Benzoate nasal in situ gel produce extended and site specific drug delivery. Keywords: Nasal drug delivery, Rizatriptan Benzoate, In Situ nasal gel, Mucoadhesion.
Authors and Affiliations
Piyush Agarwal
Keywords
Related Articles
- EP ID EP417343
- DOI -
- Views 132
- Downloads 0
GLEEVEC (IMATINIB): A BREAKTHROUGH IN CANCER TREATMENT
Deregulated protein tyrosine kinase activity is central to the pathogenesis of human cancers. Targeted therapy in the form of selective tyrosine kinase inhibitors (TKIs) has transformed the approach to management of vari...
DESIGN AND IN VITRO/IN VIVO EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF NATEGLINIDE
Aim: Nateglinide is a quick acting anti-diabetic medication whose potent activity lasts for a short duration. One of the dangerous side effects of nateglinide administration is rapid hypoglycemia, a condition that needs...
A COMPARATIVE EVALUATION OF FLEXURAL FATIGUE RESISTANCE OF PROTAPER NEXT AND PROFILE VORTEX: AN IN-VITRO STUDY.
Background: Introduction of nickel titanium file system for root canal therapy has changed the conventional approach but instrument fracture in curved and narrow root canal still remains a challenge for operator. Aim & o...
Microstylis muscifera (Jeevak): Highly Therapeutic and Endangered Orchid
In ancient times, Ashwani Kumars (Ayurvedic wonder healers) have been said to see the old, frail and emaciated body of Rishi Chyawan and decided to rejuvenate his body through medication by incorporating Ashtawarga, a gr...
Synthesis, Charectrisation of Novel Indole Based Derivatives Used as Medicinally Potent Agents
A large number of compounds containing indole nucleus have been patented, as chemotherapeutic agents, antimicrobial, cytotoxic, anti-inflammatory, antitumor, anti-convulsant, antitubercular and anti-HIV. A wide range of...