FORMULATION AND EVALUATION OF NEVIRAPINE LOADED CHITOSAN AND EUDRAGIT NANOPARTICLES FOR ANTIRETROVIRAL THERAPY
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
The goal of the present investigation was to formulate and evaluate chitosan and Eudragit® nanoparticles of nevirapine for antiretroviral therapy. Nanoparticles of nevirapine were prepared using chitosan, Eudragit® S 100, liquid paraffin and Tween-20 using Emulsion droplet coalescence method. The concentration of the polymers Chitosan and Eudragit® S 100 were selected based on the results on preliminary screening. The nanoparticles prepared were evaluated for morphology, loading efficiency, in-vitro release and in-vitro antiretroviral activities. The particle shape and morphology of the prepared nevirapine nanoparticles were determined by SEM analysis. The amount of nevirapine entrapment in the nanoparticles was calculated by the difference between the total amount of drug added to the nanoparticles and the amount of non entrapped drug remaining in the aqueous supernatant. A Franz diffusion cell was used to monitor nevirapine release from the nanoparticles. The formulations F2, F5, F6 and F8 showed good drug release from the polymer. The percentage cumulative drug release after 12 hours was 98, 99.06, 98.3 and 99.6% respectively. Formulations 6 out of 8 showed good drug release from the polymer, the percentage cumulative drug release after 12 hours were in the range of 97-99.6%. Among the six formulations F5 (2.5% Chitosan & 1 % Eudragit® S 100) showed maximum drug release in 12 hours diffusion study and good entrapment efficiency
Authors and Affiliations
Mahajan Ashwini A , Surajj Sarode , PR Patil , AV Patil
Keywords
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