FORMULATION AND EVALUATION OF SOLID DISPERSION OF LOPINAVIR BY USING DIFFERENT TECHNIQUES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 9
Abstract
Poor aqueoussolubility is the major drawback for the various types of drugs and many approaches have been introduced for the enhancement of solubility of such drugs. Solid dispersion is one of the technique adopted for the formulation of such drugs.The main objective of the present investigation was to improve theSolubility and dissolution rate of Lopinavir(LVR), a poorly water-solubledrug by solid dispersion technique using a water-soluble carrier, Soluplus. Among the various solid dispersion techniques Solvent Kneading Method used to prepare the solid dispersion in various ratios such as 1:0.5, 1:1 and 1:2. The differential scanning Calorimetry and x-ray diffraction studies demonstrated that enhanced solubility and dissolution rate from solid dispersion due to the decrease in the crystallinity. Solid dispersions were characterized for drug content, solubility study, dissolution behavior, XRD study, DSC study and SEM analysis. Finally Solid dispersion was formulated into conventional dosage form such as Tablet.
Authors and Affiliations
Pekamwar S. S. , Kankudte A. D. , G. K. Kale
Keywords
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- EP ID EP158939
- DOI 10.7897/2230-8407.069130
- Views 117
- Downloads 0
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