FORMULATION AND EVALUATIONOF ITRACONAZOLE ETHOSOMAL GEL
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 2
Abstract
Optimization of drug delivery through human skin is important in modern therapy. Recently, the transdermal route vied with oral treatment as the most successful innovative research area in drug delivery. The aim of present study is to Formulate and undergo Evaluation study of Itraconazole ethosomal gel. Preparation of Itraconazole ethosomes was followed by cold method, ten different formulations of Ethosomes were prepared by using different concentrations of polymer i.e., Soya Lecithin (2-5%) and Ethanol (20-50%). The best achieved ethosomal vesicles suspension, was incorporated into carbopol gel(1%, 1.5%, 2% w/w). Gel was evaluated with different parameters like its organoleptic character, pH measurement, Entrapment efficiency, drug content, Content uniformity, SEM and Drug release. Ethosomes containing 30% w/w ethanol and prepared by sonication showed highest value respect to all other formulation; so it is concluded that ethosomal prepared by sonication and containing 30%w/w ethanol as the best formulation considering all other aspects. The optimized formulation wasIF8 (30% alcohol) showed the drug release of 89.3%,The order of drug release for optimized gel formulation was found to be First order. Percentage drug accumulation into skin was also found to be maximum by the ethosomes containing 30% w/w ethanol. This showed effective subdermal deposition and indicates better subdermal action for fungal infections. With these findings it can be summarized that Itraconazole ethosomes are promising system in topical drug delivery for treatment of fungal disorders.
Authors and Affiliations
Dileep P*, , Vijaya Vani CH S , Uma Maheshwar Rao V
Keywords
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