Formulation and Evalution Of Sustained Release Effervescent Floating Tablets of Nateglinide
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 4
Abstract
Nateglinide is a novel, exceedingly physiologic, glucose regulator lately ratified for the handling of type-2 diabetes mellitus. Nateglinide has a rapid commencement and diminutive duration of insulinotropic action those outcomes in decline of glucose level. The persistence of this study is to develop a floating tablet of Nateglinide to boost its bioavailability and sustained action. Tablets were prepared by direct compression method, using Ethyl cellulose, Carbopol 930 and pvpk-30. Tablets were evaluated for in vitro drug release features like hardness, thickness, friability, weight variation and floating properties. Additional tablets were evaluated for In vitro drug release studies for 24 hours. The tablets unveiled controlled and prolonged release while moving over the dissolution medium, polymer rearrangement played a critical role.
Authors and Affiliations
Tellagorla Thriveni, H. V. Gangadharappa, Panchumarthy Ravisankar2, Akhil Nair, K. Leelavathi2
Keywords
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