Formulation And In-Vitro Evaluation Of Furosemide Gastroretentive Multiparticulate System
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
The aim of the present study was to develop formulation of Furosemide to maintain constant therapeutic levels of the drug for over 12 hrs. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Then the formulation was developed by using different concentrations of polymers of various grades of HPMC and Guar gum. Gastroretentive floating beads of Furosemide were prepared with an aim to provide the drug for prolonged period of time in the stomach. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits Among all the formulations the formulations prepared by using Guar gum were in the concentration of 120mg (F4) showed maximum drug release 99.76% in 12 hours. Hence F4 formulation is optimized. It followed zero order release kinetics mechanism.
Authors and Affiliations
*Zaara Majeed, A, , Asfia Kauser,, Ayesha Haseena,, Faheem Unnisa Begum,, Afreen Jahan
Keywords
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