Formulation and in-vitro evaluation of levofloxacin floating tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 1
Abstract
Gastroretentive floating tablets of Levofloxacin were successfully prepared with hydrophilic polymers like HPMC K4M, Carbopol 934, HPMC5cps, Xanthan gum. From the compatibility studies for drug and excipients it was observed that there was no interaction between drug and excipients. The formulated batches were evaluated for physicochemical parameters like hardness, thickness, weight variation, friability, drug content, floating lag time and swelling index. The physical properties like hardness, thickness, weight variation and friability of all batches complied with the pharmacopoeial specifications. The drug content of all tablets was in the range of 74.9 – 95.3%. Floating properties from the evaluation results it was observed that the tablets containing Xanthan gum and HPMC K4M, F11 showed greater floating lag time and when compared to other prepared formulation. Swelling index of floating tablets showed significant differences in their swelling index in the order of Xanthan Gum > HPMCK4 > Ethyl cellulose>Carbopol 934.
Authors and Affiliations
A. Anusha, D. Jeevan Mani Babu, B. Nagendra Babu
Keywords
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