Formulation and In vivo Evaluation of sustained release pellets of bosentan by pan coating process
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 5
Abstract
The aim of the present study was to develop sustained release pellets of bosentan with eudragit RL 100 as rate retarding polymer by pan coating process. The prepared pellets were evaluated for drug content, particle size, subjected to Scanning Electron Microscopy (SEM), FT-IR and Differential Scanning Calorimetry (DSC) and evaluated for in vitro release. The drug content was in the range of 19.07% to 21.37%. The mean particle size of the drug loaded pellets was in the range 703-790 μm. It was found that among the various batches of formulations AF-9 and wasfound to release the drug over an extended period of time, i.e. up to 18 hrs. SEM photographs confirmed that the prepared formulations were spherical in nature with a smooth surface. The compatibility between drug and polymers in the drug-loaded pellets was confirmed by FT-IR and DSC studies. In vivo bioavailability studies indicated significance difference between bosentan coated pellets and pure drug. Therefore, the present bosentan coated pellets is considered to be potentially useful for the treatment where improved patient compliance and convenience is expected.
Authors and Affiliations
G. Venkata Ramireddy
Keywords
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