Formulation Design and Optimization of Expandable Gastro Retensive Film for Controlled Release of Propranolol Hydrochloride
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 7
Abstract
Abstract:The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in the gastrointestinal tract. The purpose of the research work is to formulate and optimize the gastroretensive film(GRF) containing Propranolol hydrochloride in order to prolong the release time and improve the bioavailability. Five basic gastroretensive films were developed by solvent casting method for preliminary trial . The best formulation was subjected for two factor two level design approach. Independent variables selected were concentrations of Eudragit S 100 (X1) and Eudrajit RL 100 (X2) and dependent variables were Folding Endurance (Y1) Tensile strength (Y2) Elongation at break (Y3) and in vitro drug release (Y4). The results of the study indicate optimized formulation (P2) exhibit folding endurance 114, tensile strength 1.3 kg mm2, Elongation at break 22% and in vitro release 46.5 % for 12h. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed non-Fickian diffusion mechanism.The gastro retensive formulations can be used in diseases where an extended release of propranolol is required. Keywords: Propranolol hydrochloride,Gastroretensive expandable film,Optimization.
Authors and Affiliations
Shifana M
Keywords
Related Articles
- EP ID EP397684
- DOI -
- Views 122
- Downloads 0
Self-Reported Knowledge and Attitude of Emergency Physicians and Residents Regarding Preparedness for Radiological Emergencies in the Aseer Region, Kingdom of Saudi Arabia
Abstract: Radiological accident can have a huge impact on public health. Emergency physicians should be prepared to respond to potential radiation emergencies by improving their knowledge and attitude regarding radiation...
Haemovigilance Study in a Tertiary Care Hospital in Western Odisha
Blood transfusion is a routine, life-saving medical intervention which is generally regarded as safe when done appropriately, but it is not absolutely free from adverse reaction. The aim of the study was to analyze the A...
Prescribing Pattern and Appropriateness of Antimicrobials Use in Pediatrics for Gastroenteritis in a Tertiary Care Teaching Hospital
Abstract:The Present study was carried out to analyse the prescribing pattern of drugs and appropriateness of antimicrobials use in gastroenteritis in hospitalized children. It was a prospective, observational, single ce...
Factors That Influences on Standard Precautions among Nurses in Tertiary Hospital Lahore Pakistan
Abstract: Employing standard precautions means taking precautions with everybody. If precautions are taken with everyone, health care workers do not have to make assumptions about people's lifestyles and risk of infectio...
Effect of Organizational Ethical Climate on Physician–Patient Relationships
Abstract:The objective is to explore the effects of law and code-oriented and caring-oriented organizational ethical climates on physician–patient trust and interactions. A questionnaire survey was adopted and physicians...